Dr. Somesh Baranwal

Contact Info
Dr. Somesh Baranwal
+918901054147
Room 522, South Block, Academic Building Central University of Punjab, Main Campus VPO Ghudda Bathinda 151401
Dr. Somesh Baranwal

Associate Professor (Ramalingaswami Fellow)
Department of Microbiology

School of Basic Sciences

India’s International Fellows

https://www.indiascienceandtechnology.gov.in/hi/india-international-fel…

Specialisation: Cancer Biology

 

 

 

Qualification

Degree/ Certificate

University /Board

Year

Subject/ Specialization

Ph. D.

Department of Chemistry, Bose Institute, Kolkata, India (Thesis awarded from Jadavpur University, Kolkata

Title of the PhD Thesis: “Mechanisms of antibiotic resistance in enteric bacteria”

2004

Microbiology and Molecular Biology

M.Sc.

Dr. B R Ambedkar University, Agra

1997

Zoology

B.Sc

Agra University, Agra

1995

Biology and Chemistry
Experience
Teaching Experience

Position

Period

Associate Professor, Central University of Punjab, Bathinda, India

October 2022 onward
Assistant Professor and Ramalingaswami Fellow, Central University of Punjab, Bathinda, India July 2015 - October 2022
 
Research Experience

Position

Period

Instructor (Faculty), Virginia Commonwealth University, Richmond, VA, USA

Massey Cancer Centre              

June 4th  2012- June 30th 2015

Postdoctoral Associate University of Rochester, Rochester ,NY, USA                           

July 2010- May 2012

Postdoctoral Researcher LSU Health Science Centre, New Orleans, LA, USA 

Stanley S Scott Cancer Centre   

May 2007- June 2010

Post-doctoral Fellow, School of Dental Medicine University of Pennsylvania, Philadelphia, PA, USA               

Oct 2004- May 2007
Administrative Experience:
  1. Central University of Punjab,Bathinda Virtual Lab, Nodal officer (An Initiative of Ministry of Educatio Under the National Mission on Education through ICT)  https://www.vlab.co.in
  2. Member, Academic Council,Central University of Punjab, Bathinda.
  3. Academic and Administrative Committee of Department of Microbiology: Convener (2020-Present)
  4. Board of Studies Department of Microbiology: Member.
  5. Day Care Centre: Member (2018-August to 2021)

 

Research Area

Research Areas

  • Molecular and Cellular Biology of Gastro-intestinal Cancer.
  • Host-pathogen interaction in Enterobacteriaceae
  • Antibiotic resistance mechanism in Enteric bacteria 

 

 

Research Grants/Projects
Research Thrust

Research Grants
  1. Role of Integrin binding protein, Kindlin in colon cancer progression (Department of Biotechnology) ₹ 8.8 million grant, including a fellowship from July 2015 to June 2020.
  1. Role of Nischarin in the regulation of intestinal apical epithelial junction Rs 49.20 Lakhs (36 Months)Department of Science and Technology, New Delhi India
  1. Identification and characterization of the functional significance of gastric cancer stem cells. Rupees 10 Lakhs 24 Month University Grant Commission, New Delhi, India
  1. Role of OmpU of Vibrio cholerae in the disruption of Intestinal Intestinal Junctional barrier Rupees 3 Lakhs (24 Months) Research Seed Money grant (RSM), Central University of Punjab (CUP), Bathinda

 
Professional Affiliation
  • Life Member of Indian Society of Cell Biology
  • Life Member of Indian Science Congress Association
  • Life Member of Indian Association for Cancer Research
  • Member of the American Association for Advancement of Science, 2009 to 2010
  • Associate member of American Association for Cancer Research, 2012 to 2018
  • Full membership of Sigma XI honor society, 2012 to 2018
Professional Recognition/Awards/Scholarships
  • Recipient of Faculty Research Award from Central University of Punjab, Bathinda on 10th Foundation Day under the category cumulative Impact Factor more than 15 of research publications in the academic year (2017-18). 
  • Selected for the prestigious Ramalingaswami Re-entry Fellowship of the Department of Biotechnology for the year 2013-2014.
  • Qualified Joint CSIR-NET for Lifetime Lectureship (two times) June 2001 and December 2001 conducted by a Council of Scientific and Industrial Research (CSIR) India.
  • Qualified Graduate Aptitude Test in Engineering (GATE) in March,1999 conducted by Indian Institute of Technology, Delhi, India Percentile Score 98.09 with (All India Rank 25).
Research Collaboration

1. Department of Chemistry Central University of Punjab

2. Department of Pharmaceutical Sciences, Central University of Punjab

3. Prof Mohan Gurjar MD, FRCC Department of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow Uttar Pradesh India (NIRF Ranking 5)

Publications

Peer Reviewed Research Paper

  1. Design, synthesis and evaluation of 4-phenyl-1,2,3-triazole substituted pyrimidine derivatives as antiproliferative and tubulin polymerization inhibitors Ashish Ranjan Dwivedi,Vijay Kumar, Ravi Prakash Yadav,Naveen Kumar,Kailash Jangida,Piyush Anand, Deepak Kumar,Sharma Somesh Baranwal,Vinod Kumar; Journal of Molecular Structure Volume 1267, 5 November 2022, 133592 [IF 3.841]

  2. Structure, regulation, and host interaction of outer membrane protein U (OmpU) of Vibrio species HA Ganie, A Choudhary, Somesh Baranwal Microbial Pathogenesis Volume 162, January 2022, 105267 https://doi.org/10.1016/j.micpath.2021.105267 [IF3.848]

  3. Microbiological evaluation of raw and pasteurized milk from Malwa region of Punjab, India. Sarita, Vamshi Krishna Manikonda, Pooja Gupta, Somesh Baranwal* (Manuscript accepted in Annals. Food Science and Technology, (ISSN: 2065-2828) ([IF-N/A]
  4. Ashish R Dwivedi; Vijay Kumar; Harmeet Kaur; Naveen Kumar; Ravi P Yadav; P Ramarao; Somesh Baranwal* and Vinod Kumar Anti-proliferative Potential of Triphenyl Substituted Pyrimidines Against MDA-MB-231, HCT-116 and HT-29 cancer cell lines, Bioorganic & Medicinal Chemistry Letters 2020 Oct 15;30(20):127468. doi: 10.1016/j.bmcl.2020.127468 [IF 2.42]
  5. Verma S, Pathania AS, Baranwal S, Kumar P. (2020) Synthesis and in silico studies of quinazolinone derivatives as PARP-1 inhibitors. Letters in Drug Design and Discovery, 2020, 17(12), DOI : 10.2174/1570180817999200719152959 [IF 1.17]
  6. Bhardwaj N, Choudhary D, Pathania A, Baranwal S, Kumar P, Synthesis and molecular docking studies of quinoline derivatives as HIV non-nucleoside reverse transcriptase inhibitors, Turkish Journal of Chemistry, 2020, 44, 1-19 [IF 0.99].
  7. Gupta P, Yadav RP, Baranwal Somesh*. Commentary: MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice. Front Immunology 2019 Nov 26; 10:2649. doi: 10.3389/fimmu.2019.02649 (IF 6.429)
  8. Maziveyi M, Dong S, Baranwal Somesh, Mehrnezhad A, Rathinam R, Huckaba TM, Mercante DE, Park K, Alahari SK. Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Cancer Research 2019 May 1;79(9):2152-2166. doi: 10.1158/0008-5472.CAN-18-0842 Epub 2019 Jan 11. (IF 9.125)
  9. Somesh Baranwal*, Shiv G. Rawat, and Pooja Gupta miR-301, pleiotropic microRNA in Regulation of Inflammatory Bowel Disease and colitis-associated cancer Opinion article Frontiers in Immunology doi: 10.3389/fimmu.2018.00522 (IF 6.429)
  10. Maziveyi M, Dong S, Baranwal Somesh, Alahari SK. Nischarin regulates focal adhesion and Invadopodia formation in breast cancer cells. Molecular Cancer. 2018 Feb 7; 17(1):21. doi: 10.1186/s12943-018-0764-6 (IF 6.204)
  11. Baranwal Somesh* Commentary: HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing of CD44 during epithelial-mesenchymal transition. Front Cell Dev Biol. 2017 Oct 16; 5:91. doi:10.3389/fcell.2017.00091 (IF 5.180)
  12. Patel NJ, Sharon C, Baranwal Somesh, Boothello RS, Desai UR, Patel BB. Heparan sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase. Oncotarget. 2016 Dec 20; 7(51):84608-84622. doi: 10.18632/oncotarget.12358. (IF 5.168)
  13. Baranwal Somesh Book Review Article: Gastrointestinal Physiology and Diseases Methods and Protocols Front Cell Infect Microbiology 2017; 7: 319. Published online 2017 Jul 14. doi: 10.3389/fcimb.2017.00319 (IF 4.200)
  14. Dong S, Baranwal Somesh, Garcia A, Serrano-Gomez SJ, Eastlack S, Iwakuma T, Mercante D, Mauvais-Jarvis F, Alahari SK. Nischarin inhibition alters energy metabolism by activating AMP- activated protein kinase. J Biological Chemistry 2017 Oct 13; 292(41):16833-16846. doi: 10.1074/jbc.M117.784256 (IF 4.125)
  15. Dongdong Wang, Nayden G. Naydenov, Alex Feygin, Somesh Baranwal, John F. Kuemmerle, Andrei Ivanov. Actin-depolymerizing factor and cofilin-1 have unique and overlapping functions in regulating intestinal epithelial junctions and mucosal inflammation American Journal of Pathology (IF 4.591)
  16. Susana Lechuga, Somesh Baranwal, Andrei I. Ivanov.   Actin interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions. Am J Physiol Gastrointest. Liver Physiol. 2015 May 1; 308 (9):G745-56. (IF 3.72) 
  17. Chetna Sharon, Somesh Baranwal, Nirmita J. Patel, Daniel Rodriguez-Agudo, William M. Pandak, Adhip PN Majumdar, Geoffrey Krystal, Bhaumik B. Patel. 2015 Inhibition of Insulin-like Growth Factor Receptor/AKT/Mammalian Target of Rapamycin Axis Targets Colorectal Cancer Stem Cells by Attenuating Mevalonate-Isoprenoid Pathway in vitro and in vivo. Oncotarget. 2015 Jun 20;6(17):15332-47. (IF 6.63)
  18. Susana Lechuga* , Somesh Baranwal*, Chao Li , Nayden G. Naydenov, John F. Kuemmerle, Vera Dugina ,, Andrei I. Ivanov Loss of γ-cytoplasmic actin triggers myofibroblast transition of human epithelial Cell Mol Biol Cell. 2014 Oct 15; 25(20):3133-46            (IF 5.861)
  19. Jagrut Patel*, Somesh Baranwal*, Ian Love, Nirmita Patel, Steven Grossman, Bhaumik B. Patel. Inhibition of C-terminal Binding Protein attenuates Transcription Factor 4 signaling to selectively target Colon Cancer Stem Cells. Cell Cycle. 2014 Nov 15; 13(22):3506-18. (IF 5.006)
  20. Patel, N*, Karuturi, Rajesh, Al-Horani, Rami*, Somesh Baranwal, Patel, Jagrut; Desai, Umesh; Patel, Bhaumik. Synthetic, Non-Saccharide Glycosaminoglycan Mimetics Selectively Target Colon Cancer Stem Cells (*denotes equal contribution) ACS Chemical Biology 2014 Aug 15;9(8):1826-33. (IF 5.442)
  21. Nayden G. Naydenov*, Somesh Baranwal*, Shadab Khan, Alex Feygin, Pooja Gupta and Andrei I. Ivanov Novel mechanism of cytokine-induced disruption of epithelial barriers: janus kinase and protein kinase D dependent down regulation of junction protein expression Tissue Barriers. 2013 Oct 1;1(4):e25231 A Landes Bioscience Journal established in 2013 International Peer reviewed
  22. Prachi Jain, Somesh Baranwal, Amanda P. Struckhoff, Rebecca A. Worthylake, Suresh K Alahari LKB1 interacts with Nischarin to regulate breast tumor growth and metastasis. J Biol Chem. 2013 May 31; 288(22):15495-509 (IF 4.773)
  23. Michael J. Walters*, Angela C. Brown*, Thomas C. Edrington, Somesh Baranwal, Yurong Du, Edward T. Lally, and Kathleen Boesze-Battaglia Contact with Membrane Lipids Induces Changes in Aggregatibacter actinomycetemcomitans Leukotoxin Secondary Structure. Molecular Oral Microbiology 2013 Oct; 28(5):342-53  (IF 2.641)
  24. Somesh Baranwal, Nayden G. Naydenov, Gianni Harris, Vera Dugina, Kathleen G. Morgan, Christine Chaponnier, Andrei I. Ivanov, Non-redundant roles of cytoplasmic beta- and gamma-actin isoforms in regulation of epithelial apical junctions Mol Biol Cell. 2012 Sep; 23(18):3542-53. (IF 5.861)
  25. Nayden G Naydenov, Bryan Brown, Gianni Harris, Michael R Dohn, Victor M Morales, Somesh Baranwal, Albert B Reynolds, Andrei I. Ivanov A membrane fusion protein alpha-SNAP is a novel regulator of epithelial apical junctions PLoS One. 2012;7(4):e34320 (IF 4.11)
  26. Somesh Baranwal, Wang Y, Rathinam R, Lee J, Jin L, McGoey R, Pylayeva Y, Giancotti F, Blobe GC, Alahari SK. Molecular characterization of the tumor-suppressive function of Nischarin in breast cancer. J National Cancer Inst. 2011 Oct 19;103 (20): 1513-28 (IF 14.697)
  27. Yanfang W*, Shenouda S*, Somesh Baranwal*, Rathinam, R. Jain P., Hazari S, Dash S, Alahari SK. Integrins alpha-5 and alpha-6 regulate cell cycle by modulating the Chk1 and Rb/E2F pathways to affect breast cancer metastasis. Molecular Cancer. 2011 Jul 13; 10:84. (*Denotes equal contribution) (IF 5.40)
  28. Fong KP, Pacheco CM, Otis LL, Somesh Baranwal, Kieba IR, Harrison G, Hersh EV, Boesze-Battaglia K, Lally ET. Actinobacillus actinomycetemcomitans leukotoxin requires lipid micro domains for target cell cytotoxicity. Cellular Microbiology 2006 Nov; 8(11): 1753-67. (IF 5.625).
  29. Somesh Baranwal, Dey K, Ramamurthy T, Nair GB, Kundu M. Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae. Antimicrobial Agents Chemotherapy 2002 Aug; 46(8): 2676-8 (IF 4.672).

Book Chapter

1. Nirmita Patel, Somesh Baranwal, and Bhaumik B. Patel. A Strategic Approach to Identification of Selective Inhibitors of Cancer Stem Cells Glycosaminoglycan, Chemistry and Biology Methods Mol. Biol. 2015;1229:529-41.

Review Article

  1. Somesh Baranwal, Alahari SK Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis. Current Drug Targets. 2011 Jul 1; 12(8):1194-201 (IF 3.061)
  2. Somesh Baranwal, Alahari SK. miRNA control of tumor cells invasion and metastasis. Int J Cancer. 2010 Mar 15; 126 (6): 1283-90. (IF 5.44)
  3. Somesh Baranwal, Alahari SK. Molecular mechanisms controlling E-cadherin expression in breast cancer. Biochem. Biophys. Res. Commun. 2009 Jun 19; 384 (1):6 -11 (IF 2.595)
 
 

 

Research Guidance

Ph.D. 

Ongoing:

  1. Ravi Prakash Yadav (CSIR-SRF)
  2. Aaina (UGC-SRF)
  3. Tushar Midha (CSIR-JRF)

 

M.Sc. dissertation

2021-2023 (Ongoing)

1. Satyarth Pandey

2. Rashmi Deora

3. Shreevar 

4. Mansi Goswami

5. Subodh Pradhan

6. Vishaka 

 

2020-2022 (Completed)

1. Vyshnav PV

2. Anuja Banra 

3.Girija Sankar 

4. Ishita Gulati

 

2019- 2021

1. Gyana Ranjan Nayak

2. Mubashira Shahid 

3. Chahak Singhal (Joined PhD program in Jamia Millia Islamia, New Delhi)

2018- 2020

1. Ruchika Chaudhary (Assessment Developer- Biology, Trivium Education Services Private Limited) 

2. Hilal A Ganie (PhD IISER, Pune)

3. Kajal,

4. Paramita Pakhira.

2017-2019

1. Moumita Ghosh (PhD scholar, Regional Center for Biotechnology, Faridabad),

2. Anwesha Barman,

3. Abhishek Ramachandra Panigrahi (ICMR Senior Research Fellow, Central University of Punjab, Bathinda) 

4. Cherish Prashar (Junior Research Fellow, National Institute of Malaria Research, New Delhi) 

5. Dinesh Kumar Dhawan (PhD students, IIT, Guwahati)

2016 - 2018

Ekta Kashyap (Research Associate, Glenmark Pharmaceuticals Limited, Mumbai), Sarita (Evelyn learning system, New Delhi), Dimple Garg

2015 -2017

Adarsh Shukla (Perusing Law from Himachal Pradesh University), Sunita Karki, Md Naiyaz Ahmad (JRF, Central Drug Research Institute, Lucknow), Manjeet Kaur.

Conference/ Workshops/Seminars Attended

Conference Presentations

  1. Somesh Baranwal, Role of Kindlin isoforms in colon cancer growth and Cancer stem cell phenotype 7th conclave department of Biotechnology, New Delhi 2018
  2. Naiyaz Ahmad, Shiv Govind Rawat and Somesh Baranwal: Antibiotic susceptibility analysis for Vibrio species in water bodies of Bathinda, Punjab MSDSA-2017, Lucknow India
  3. Somesh Baranwal, Sharon C. Patel NJ and Bhaumik B Patel. Inhibition of Insulin-like growth factor-1 receptor-Akt-Mammalian target of rapamycin axis selectively attenuates CCS phenotype through regulation of β-catenin/TCF4 signaling via modulation of protein prenylation. VCU Massey Cancer Center Research Retreat May 22nd 2015 Richmond VA.
  4. Chetna Sharon, Somesh Baranwal, Bhaumik B Patel IGF-1R attenuates Cancer Stem cell growth through inhibition of Mevalonate Biosynthetic pathway by preferentially targeting isopentenyl diphosphate delta isomerase 1. VCU Massey Cancer Center Research Retreat May 22nd 2015 Richmond VA.
  5. Rio Boothello, Nirmita Patel, Chetna Sharon, Somesh Baranwal, Bhaumik B Patel. Non- anticoagulant heparin hexasaccharide selectively inhibit Cancer stem Cell. VCU Massey Cancer Center Research Retreat, May 22nd 2015 Richmond VA.
  6. Nirmita Patel, Nehru Sankaranarayanan, Balaji Nagarajan, Rio Boothello, Somesh Baranwal, Steven Grossman, Umesh R Desai, Bhaumik B. Patel. A unique non-saccharide mimic of heparin hexasaccharide selectively inhibits Cancer stem Cell growth via a novel p38MAPK-CtBP2-TCF4 axis. VCU Massey Cancer Center Research Retreat May 22nd 2015 Richmond VA
  7. Patel J*, Somesh Baranwal*, IM Love, NJ Patel, A Raqhibana, C Sharon, BB Patel C-Terminal Binding Protein is an important therapeutic target for Colorectal Cancer to Selectively aim at Cancer Stem Cells by regulating β-Catenin signaling., Gastroenterology 146 (5), S-516-S-517 2014
  8. Patel NJ*, R Karuturi*, RA Al-Horani*, Somesh Baranwal, J Patel, UR Desai, BB Patel Synthetic, non- saccharide glycosaminoglycan mimetics selectively target colon cancer stem cells Gastroenterology 146 (5), S-84-S-85 2014 Sharon Chetna, Somesh Baranwal, J Patel, NJ Patel, BB Patel. Inhibition of Insulin- Like Growth Factor Receptor Activity Attenuates Colon Cancer Stem Cells Growth and Self-Renewal by Targeting Mevlonate-Isoprenoid Metabolism, Gastroenterology 146 (5), S-692 2014
  9. Somesh Baranwal, Nayden G. Naydenov and Andrei I. Ivanov, “Non-redundant functions of cytosolic alpha and beta -actin isoforms in regulating epithelial apical junctions” Poster Presentation at Gordon Research Conference on Cell Contact & Adhesion – Cell Interactions and Tissue Organization in Health and Disease. June, 2011.
  10. Prachi Jain, Somesh Baranwal, Suresh K. Alahari. Tumor suppressor LKB1 cooperates with the integrin-binding protein Nischarin to inhibit breast cancer” in poster presentation in 102 Annual AACR Annual meeting Orlando, FL. USA April, 2011.
  11. Lianjin Jin, Somesh Baranwal, Yanfang Wang and Suresh K. Alahari. October, 2010 “MiR-23b promotes human breast cancer growth and metastasis by down-regulating Nischarin expression” poster presentation in Twenty fourth annual Graduate Research Day LSU Health Science Centre, New Orleans, LA. USA.
  12. April, 2010 Invited talk on “Molecular Characterization of Tumor Suppressive Function of Nischarin in Breast Cancer” at Department of Obstetrics and Gynaecology University of Chicago, Illinois.
  13. February, 2010 Oral presentation on “Generation and preliminary characterization of Nischarin Integrin binding domain deleted knockout mice” in the Department of Biochemistry and Molecular biology LSUHSC, New Orleans. LA USA.
  14. Somesh Baranwal, Y Wang, R. Rathinam and S. K. Alahari. November, 2009 Tumor suppressor function of Nischarin in Breast cancer in twenty third annual Graduate Research Day LSU Health Science Center. New Orleans, LA .USA.
  15. Dong S, Somesh Baranwal, M. Maziveyi, S. Alahari Nischarin-integrin interaction and downstream signaling regulate mouse mammary development and tumorigenesis Mol. Biol. Cell, December 15, 2013 vol. 24 # 888
  16. Somesh Baranwal, Walch A, Lakins J, Weaver VM and Alahari SK. Nischarin over expression inhibits metastasis by restoring epithelial markers in metastatic breast cancer cells Mol. Biol. Cell 19 (suppl), #. 1436/B655 (Abstract) 2008
  17. Wang, Y, Lavezzi, T, Walch Amelia, Milosavljevic T, Somesh Baranwal, S.K.   Alahari. December, 2007 “MicroRNA Profiling of Human Breast Cancer Cell Line MDA-MB-231 (sub-line 4175) and MCF10A. Mol. Biol. Cell 19 (suppl), #. 1436/B655
  18. April 2007, Invited talk “Actinobacillus actinomycetemcomitans Leukotoxin /LFA-1 interaction” at the laboratory of Immunology, National Institute of Aging Baltimore,

 

Conference/ Workshops/Seminars Organised
 
 

 

Peer Recognition

Editorial Board Member of Frontiers in Oncology; Adhoc Reviewer for Indian Journal of Microbiology, Indian Journal of Microbiology and Pathology, PLoS One, Molecular Cancer, Tissue Barrier, Journal of Cancer Science & Therapy, Gut, Tissue Barrier.

Invited Talks/ Resource Person
National Level
1. Invited webinar "COVID-19 Immune Response and Vaccine Development" Tripura Central University dated 2020-09-22
2. Awareness Raising and Networking Event invited Lecture "Isolation, Characterization, and, Poultry application of Lytic Phages" Horizon 2020 Green Deal Calls Co-Funded by the Department of Biotechnology International (within country) dated 2020-11-03
Citations

Google Scholar h-index: 22; Citations: 1495

Scopus h-index: 17; Citations: 884

Total Impact Factor of Publications = 170