Dr. Jyoti Parkash

Contact Info
Dr. Jyoti Parkash
7986980164
Dr. Jyoti Parkash

Assistant Professor

Department of Zoology 

School of Biological Sciences

Central university of Punjab Bathinda, Ghudda, Punjab, 151401

Email id: jyoti.parkash@cup.edu.in    jtprksh.sharma@gmail.com

Mobile: 7986980164, 8699212464

Qualification

Ph. D. from Guru Nanak Dev University Department of Biotechnology in year January 2008

M.Sc. from  Guru Nanak Dev University Life Sciences (Department of Zoology) in year 2002

BSc. from Himachal Pradesh University, Medical Sciences in year 2000

Experience
Teaching/Research Experiences:  August 2008 to Till date (Continue)

Name of Institute

Position

Start Date

End Date

Department of Zoology, Central University of Punjab, Bathinda

Assistant Professor

2015

Till Date

Department of Biotechnology, DAV University, Jalandhar, Punjab

Assistant Professor

2014

2015

Jean-Pierre Aubert Research Center

INSERM U837, place de Verdun

59045 Lille cedex, France

Postdoctoral Fellow/Research Scientist

2008

2014

 

 

 

Research Area

 

 

Research Interests

My research interest area is to examine and get more insight into the various neuronal and non-neuronal populations that play an essential role in regulating the GnRH secretion in the adult brain and various neuroendocrine disorder. I am currently working on the KNDy neurons, which are essential for the GnRH pulse generation. Hypothalamus-pituitary-gonads are the integrated system responsible for releasing the GnRH and gonadotropin required for the reproductive axis's proper functioning. Multiple neuronal and non-neuronal cell populations work in synchronization to carry out reproduction, the onset of puberty and fertility. In the recent year, research facilitated to know the precise function KNDy neurons in these critical physiological processes which make organisms competent for reproduction. KNDy neurons characterize by the co-expression of Kisspeptin, Neurokinin B (NKB) and Dynorphin. These neuronal subpopulations are conserved across the multiple species and make them an essential regulator of GnRH neurons. GnRH neurons act as a central channel in sending the brain signal to pituitary and gonads that are important for spermatogenesis, ovulation and reproductive cycle. These neurons are essential for releasing GnRH and gonadotropins during the various phases of the ovarian cycle. GnRH neurons are not directly receiving most of the exogenous and endogenous cues. In the hypothalamus, afferents from different neuronal population interact with these neurons in the preoptic area and median eminence of the hypothalamus to transmit various signals to these neurons. One such neuronal population is KNDy neurons that interact with GnRH neurons in the median eminence and are responsible for releasing the GnRH and LH/FSH that are important for the onset of puberty and to maintain the reproductive function of an organism. Close apposition of the KNDy processes with GnRH neurons makes these KNDy a vital regulator that modulates these neurons activity in the hypothalamus. Kisspeptin secreted from these neurons acts as an output signal to GnRH while NKB and Dynorphin are stimulator and terminator of the GnRH pulse. These populations reside in the Hypothalamus region of the brain where they reciprocally act on each other and lead the GnRH pulse generation. There is less known about the partner and players through which these neuronal population relay cues to regulates the GnRH populations. The new finding in context with the KNDy neurons will allow finding out medical interventions that can cure and prevent multiple neuroendocrine disorders.

      Under neurodegenerative disorders (NDDs), there is a permanent damage in the neuronal network due to deficiency in the regeneration and repair of neuronal cells. In stroke and other neurodegenerative diseases, glutamate clearance from extra synaptic space is hampered due to which glutamate-NMDA interactions cause hyperexcitability of postsynaptic neurons. In the downstream signaling, increased calcium (Ca2+)  influx leads to mitochondrial dysfunction, neuronal excitotoxicity and cell death (Choi, 1994). Astrocytes maintain glutamate homeostasis and thus regulate concentration of Ca2+ in the cell but with aging the sustenance of homeostasis hampers that leads to excitotoxicity. Astrocytes show 2 phenotypes A1 (neurodegenerative) and A2 (neuroprotective) under different neurodegenerative conditions and the ratio of these two is very critical in the overall sustenance of the system. His lab is working upon screening of natural compounds that might contribute towards reversing the effects of neurodegeneration and establish a ratio of A1/A2 phenotypes that are majorly directed towards neuroprotection.  The work circles around molecular docking of natural compounds with the proteins specifically associated with NDDs and establishing methods for protecting against the same. Dr. Parkash is also working on multifunctional inhibitors from natural compounds alone and in combination to target various pathological hallmarks of Alzheimer’s disease (AD) and Epilepsy.

Research Grants/Projects
  1. KNDy/nNOS neurons interplay : A new possible mechanism of GnRH secretion in the adult brain, from Science and Engineering Research Board, Department of Science and Technology (SERB-DST), New Delhi, under the Core Research Grant (CRG), Rs 61.5 Lakh for 3 years (2020-2023)
  2. Parkash Jyoti (Co-PI) : Multi-target paradigm in drug discovery efforts to combat Alzheimer disease, from the Council of Scientific and Industrial Research (CSIR), Rs. 31 lakh for 3 years (2019-2022).
  3. Neural-glial-endothelial tripartite interactions : Unravel the basic cell-cell regulatory Mechanisms involved in the central control of reproduction, from Science and Engineering Research Board, Department of Science and Technology (SERB-DST), New Delhi, under the Early Career Research (ECR) grant, Rs 43.5 Lakh for 3 years (2017-2020).
  4. Role for Semaphorins and its receptors in the control of sexual brain development and adult brain plasticity, from University Grants Commission (UGC), New Delhi, under Basic Scienctific Research Scheme (BSR), Rs 6 lakh for 2 years (2017-2019).
  5. Developmental origins of the metabolic syndrome : Hormone-dependent programming of the metabolic brain in physiological and pathological conditions. RSM grant from Central University of Punjab, Bathinda, Rs 3 lakh for 2 years (2016-2018).
Professional Affiliation

Name of Institute

Position

Start Date

End Date

Department of Zoology, Central University of Punjab, Bathinda

Assistant Professor

2015

Till Date

Department of Biotechnology, DAV University, Jalandhar, Punjab

Assistant Professor

2014

2015

Jean-Pierre Aubert Research Center

INSERM U837, place de Verdun

59045 Lille cedex, France

IFCPAR/CEFIFRA Fellow/Postdoctoral Fellow/Research Scientist

2008

2014
Professional Recognition/Awards/Scholarships

Years

Name of the University/Institution

2002-2005

Junior Research Fellowship (JRF), Department of Biotechnology, New Delhi, India.

2006-2007

Senior Research Fellowship (SRF), Indian Council for Medical Research, New Delhi, India.

2008-2014

Postdoctral fellowships under different programs CEFIPRA / IFCPAR / FRM / University of Turin / University of Lille France.

Awards:

2016-17

1. Recipient of Research Award for research publication with impact factor of more than 10, from Central University of Punjab.  

2. Recipient of Research Award for research publication with cumulative impact factor of more than 15, from Central University of Punjab.

2017-18

Recipient of Research Award for research publication with cumulative impact factor of more than 15, from Central University of Punjab.  

2006

Recipient of Travel Award for 7th Biennial Meeting at The Asian Pacific Society for Neurochemistry (APSN), National University of Singapore (NUS), Singapore.

2006

Recipient of Travel Award for excellent presentation at the 29th Annual Meeting of the Japan Neuroscience Society, Kyoto, Japan.

2005

Recipient of Travel Grant to attend the XXII annual meeting of The Indian Academy of Neuroscience (IAN) held on 28th-30th Jan, 2005 in Gwalior, India.

Peer Recognition:

2016- Till date

Editorial Board Member for International Journal of Biology, Pharmaceutical and Allied Sciences (IJBPAS)

2015- Till date

Editorial Board Member for Journal of Virology and Biotechnology

2012-2013

Member Society for Neuroscience (SFN)

2005-2006

Member for Asian Pacific Society for Neurochemistry (APSN)

2005-2006

Member for Japan Neuroscience Society (JNS)

2017- Till date

Life member for Indian Academy of Neuroscience (IAN)
Research Collaboration
  1. Department of Zoology, BHU Varanasi, UP, India
  2. Department of Biotechnology. Guru Nanak Dev University Amritsar Punjab, India
  3. Department of chemistry, Central University of Punjab, Bathinda, India.
  4. Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, India.
  5. MOU signed between Dr. Jyoti Parkash lab and Dr. Vincent Prevot (Director) lab U1172 INSERM, International Associated Laboratory NEUROBESE lab. In this MOU exchange of faculty and students has been signed between India and France research group. This MOU will provide us the possibility to collaborate with different research groups working in the different research prospective and also give some fluidity for the exchange of faculties and students between two universities.
Publications

Research Articles:

  1. Randeep Singh Arora, T., Prashar, V., Changotra, H., Sharma, A., Parkash, J*. (2023) Tinospora cordifolia: A potential neuroprotective agent against various neurodegenerative diseases. Journal of Herbal medicine S2210-8033(23) 00153-7 (IF: 2.682) https://doi.org/10.1016/j.hermed.2023.100775
  2. Pavneet Kaur, Kamlesh K. Gurjar, Tania Arora, Divya Bharti, Manpreet Kaur,Vinod Kumar, Jyoti Parkash, Rakesh Kumar (2023): Efficient synthesis andmechanistic insights for the formation of imidazo[1,2- ]pyridines viamulticomponent decarboxylative coupling using chitosan-supported coppercatalysts. Molecular Ctalysis Vol. 550, 113582. (Impact Factor: 5.08) https://dx.doi.org/10.2139/ssrn.4519904
  3. Gaurav Agarwal, Indu Sharma, Jyoti Parkash, Pal Dinesh Kumar, Sanjeev K Verma (2023) Surface modification of kevlar fabric with a novel sulfonyl aryl containing monomer and its influence on inter yarn friction. Vol. 35 (7) (Impact Factor: 2.1) https://doi.org/10.1177/09540083231172896
  4. Arora, T., Prashar, V., Singh R., T Singh Barwal, S. T., Changotra, H., Sharma, A., Parkash J*. (2022). Dysregulated miRNAs in Progression and Pathogenesis of Alzheimer's Disease. Molecular Neurobiology. Accepted on 28 June 2022. (IF: 5.682)
  5. Prashar V, Arora T, Singh R, Sharma A, Parkash J* (2022) Hypothalamic Kisspeptin Neurons: Integral Elements of the GnRH System. Reproductive Sciences (Impact factor-3.02) 022, 01027-5
  6. Kumar, B., Dwivedi, A. R., Arora, T., Raj, K., Prashar, V., Kumar, V., Singh, S., Parkash J*., & Kumar, V. (2022). Design, Synthesis, and Pharmacological Evaluation of N-Propargylated Diphenylpyrimidines as Multitarget Directed Ligands for the Treatment of Alzheimer's Disease. ACS chemical neuroscience, 10.1021/acschemneuro.2c00132. Advance online publication. https://doi.org/10.1021 /acschemneuro.2c00132. (IF: 5.780)
  7. Dwivedi, A. R., Kumar, V., Prashar, V., Verma, A., Kumar, N., Parkash J*., & Kumar, V. (2022). Morpholine substituted quinazoline derivatives as anticancer agents against MCF-7, A549 and SHSY-5Y cancer cell lines and mechanistic studies. RSC medicinal chemistry, 13(5), 599–609. https://doi.org/10.1039/d2md00023g. (IF: 3.470).
  8. Harish Changotra, Sargeet Kaur, Suresh Singh Yadav, Girdhari Lal Gupta, Jyoti Parkash, Ajay Duseja (2022). ATG5: A central autophagy regulator implicated in various human diseases. Cell Biochem Funct. 40(7):650-667 Impact factor 3.963
  9. Sharma, A., Duseja, A., Parkash, J., & Changotra, H. (2022). Association of IRGM gene promoter polymorphisms with hepatitis B virus infection. The journal of gene medicine, 24(7), e3433. https://doi.org/10.1002/jgm.3433 (IF: 4.152).
  10. Durbadal C. Parkash J and Arti Sharma (2022): Bioinformatics approach in the solving the puzzle of autoimmune diseases. IJBRA (Impact factor: 0.554) 18 (5) 415–459. https://doi.org/10.1504 /ijbra.2022.128245
  11. Prashar V, Arora T, Singh R, Sharma A, Parkash J* (2021). Interplay of KNDy and nNOS neurons: A new possible mechanism of GnRH Secretion in the adult brain. Reproductive Biology. Accepted 31st Aug. (Impact factor : 2.34).
  12. Arora N, Prashar V, Arora T, Singh R, Anshul Mishra, Godara, P Banerjee A, Sharma A, and Parkash J* (2021) Comparative Genomic and Network Analysis of nNOS by Using Different Bioinformatics Approaches. Current Pharmacogenomics and Personalized Medicine, 18, 1-15 (Impact factor : 1.14).
  13. Singh A, Lal B,  Parkash J, Millar RP (2021) : Gametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus: Putative underlying mechanistic cascade. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology ; 256, DOI: 10.1016/j.cbpb.2021.110642 (Impact factor : 2.23).
  14. V. Kumar, B. Kumar, A. Ranjan Dwivedi, D. Mehta, N. Kumar, B. Bajaj, T. Arora, V. Prashar, J. Parkash*, V. Kumar (2020) Design, Synthesis and Evaluation of O ‐Pentyne Substituted Diphenylpyrimidines as Monoamine Oxidase and Acetylcholinesterase Inhibitors. ChemistrySelect 5, 8021-8032 (Impact factor : 2.1).
  15. Kumar B, Dwivedi AR, S Prashar V, Gupta SK, Krishnamurthy S, Parkash J*, Kumar V* (2019) Dipropargyl Substituted Diphenylpyrimidines as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase. European Journal of Medicinal Chemistry, 177, 221-234 (Impact factor: 4.8).
  16. Kumar B, Dwivedi AR, Sarkar B, Gupta SK, Krishnamurthy S, Mantha AK, Parkash J, Kumar V: (2018): 4,6-Diphenylpyrimidine Derivatives as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 10.1021/acschemneuro.8b00220 (Impact factor: 4.21). 
  17. Parkash J, Anne Sarah L, Gallet, Balland E, Pralong F,Pasterkamp J, Prevot J, and Giacobini P, 2015: Semaphorin 7A regulates neuro-glial plasticity of the adult hypothalamic median eminence Nature Communations 6:6385. 12; 7: 10055 (Impact factor: 17.69).
  18. Jongbloets BC, Lemstra S, Schellino R, Broekhoven MH, Parkash J, Hellemons AJ, Mao T, Giacobini P, van Praag H, De Marchis S, Ramakers GMJ and Pasterkamp RJ (2017) Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nature Communications 10,8, 14666 (Impact factor: 17.69).
  19. Messina A, Langlet F, Chachlaki K, Roa J, Rasika S, Jouy N, Gallet S, Gaytan F, Parkash J, Sempere MN, Giacobini P, Prevot V (2016) MicroRNAs regulate production of hypothalamic GnRH before puberty. Nature Neuroscience 19(6):835-844  (24.88).
  20. Cimino I, Casoni F, Messina A, Parkash J, Soazik P Jamin, Sophie Catteau-Jonard, Francis C, Baroncini M, Dewailly D, Pigny P, Prescott M, Campbell R, Herbison A, Prévot V, and Giacobini P (2016) : Novel Role for Anti-Müllerian Hormone in the Regulation of GnRH Neuron Excitability and Hormone Secretion. Nature Communications 12; 7: 10055. (Impact factor: 17.69)
  21. Giacobini P *, Parkash J*, Campagne C*, Hanchate Nk, Mazure D, Prevot V (2014): Brain Endothelial Cells Control Fertility through Ovarian-Setroid-Dependent Release of Semaphorin 3A. Plos Biology 12 (3), e1001808 (Impact factor: 9.5).
  22. Bellefontaine N, chachlaki N, Parkash J, Vanacker C, Colledge W, Tassigny X, Bouret S, and Prevot V (2014): Leptin facilitates reproduction through neuronal nitric oxide signaling in the hypothalamic preoptic region in mice. Journal of Clinical investigation (Impact factor : 14.8) doi:10.1172/JCI65928
  23. Collden G,Balland E, Parkash J, Caron E, Prevot V, Bouret SG (2014):Neonatal Overnutrition Causes Early Alterations in the Central Response to Peripheral Ghrelin Molecular Metabolism 24; 4(1):15-24. (Impact factor: 8.5).
  24. Parkash J, Cimino I, Ferraris N, Casoni F, Wray S, Cappy H, Prevot V, and Giacobini P (2012): Suppression of β1- integrin in gonadotropin-releasing hormone cells distrupts migration and axonal extension resulting in severe reproductive alterations. Journal of Neuroscience (Impact factor: 7.13) 32(47): 16992-17002.
  25. Hanchate NK*, Parkash J*, Bellefontaine N, Mazur D, Colledge WH, Tassigny X, Prevot V (2012) : Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation. Journal of Neuroscience (Impact factor: 7.13) 32(3): 932-945.
  26. Hanchate NK, Giacobini P, Pierre Lhuillier, Parkash J, Cécile Espy, Fouveaut C, Leroy C, Baron S, Campagne C, Collier F, Garcia-Pineiro A, Dewailly D, Cortet-Rudelli C, Gersak K, Pugeat M, Young J, Hardelin JP, Prevot V and Dodé C (2012): SEMA3A, a Gene Involved in Axonal Pathfinding, Is Mutated in Patients with Kallmann Syndrome. PLoS Genetics (Impact factor: 9.13) 8(8): e1002896.
  27. Kumar S, Parkash J, Kumar H and Kaur G 2012 : Enzymatic removal of polysialic acid from neural cell adhesion molecule interrupts gonadotropin releasing hormone (GnRH) neuron-glia remodeling.  Molecular and Cellular Endocrinology (Impact factor : 4.1) 348(1) : 95-103.
  28. Briz V,Parkash J, Sánchez-Redondo S, Prevot V, Suñol C (2012): Allopregnanolone Prevents Dieldrin-induced NMDA Receptor Internalization and Neurotoxicity in Cortical Neurons by Preserving GABAa Receptor Functionality. Endocrinology (Impact factor: 4.75) 153(2): 847-60. 
  29. Parkash J, Tassigny X, Bellefontaine N, Campagne C, Mazure D, Scherrer VB, and Prevot V (2010): Phosphorylation of N-methyl-D-aspartic acid receptor-associated neuronal nitric oxide synthase depends on estrogens and modulates hypothalamic nitric oxide production during the ovarian cycle. Endocrinology (Impact factor: 4.75) 151: 2723 - 2735.
  30. Parkash J and Kaur G 2010: Steroid Hormones Regulate Post-Translational Modification of Neural Cell Adhesion Molecule: Implication For The Neuroendocrine Control of GnRH.  Journal of Neurological Sciences (Impact factor: 0.13) 27(2): 197-213.
  31. Vij A, Randhawa R, Parkash J and Changotra H (2016): Investigating regulatory signatures of human autophagy related gene 5 (ATG5) through functional in silico analysis. Meta gene 9:237-48. (Impact factor: 1.2).
  32. Kumar S*, Parkash J*, Kumar H and Kaur G (2009) : Interactive effect of excitotoxic injury and dietary restriction on neurogenesis and neurotrophic factors in adult male rat brain. Neuroscience Research (Impact factor : 3.3) 65(4) : 367-374.
  33. Parkash J and Kaur (2007): Potential of PSA-NCAM in neuron-glial plasticity in the adult hypothalamus: Role of noradrenergic and GABAergic neurotransmitters. Brain Research Bulletin (Impact factor: 4.07) 74(5): 317-328.
  34. Parkash J and Kaur (2007): Transcriptional Regulation of PSA-NCAM Mediated Neuron-glial Plasticity in the Adult Hypothalamus. Neuron Glia Biology (Impact factor: 6.63) 3: 299-307.
  35. Parkash J and Kaur (2005): Neuronal-Glial Plasticity in the GnRH Release in Adult Female Rats: Role of Polysialylated Form of Neural Cell Adhesion Molecule. Journal of Endocrinology (Impact factor: 4.2) 186: 397-409.
  36. Walia A, Mehta P, Guleria P, Chauhan A and Parkash J (2017) : Microbial xylanases and their application in pulp biobleaching: 3Biotech DOI: 10.1007/s13205-016-0584-6. (Impact factor: 2.40).
  37. Bellefontaine N, Hanchate NK, Parkash J, Campagne C, Seranno S, Tassigny X, Prevot V (2011): Nitric oxide as key mediator of neuron-to-neuron and endothelia-to-glia communication involved in neuroendocrine control of reproduction.  Neuroendocrinology (Impact factor: 4.9) 93: 74-89.
  38. Prevot V, Bellefontaine N, Marc Beronni, Arian Shrif, Hanchate NK, Parkash J, Celine Campagne and Sandrine de Seranno 2010: GnRH nerve terminals, tanycytes and neurohaemal junction remodeling in the adult median eminence: functional consequences for reproduction and dynamic role of vascular endothelial cells. Journal of Neuroendocrinology (Impact factor: 4.67) 22 (7): 639-649.
  39. Prevot V, Hanchate NK, Shrif A, Parkash J, Estrella C, Allet C, Campagne C, Sandrine de Seranno, Tassigny X, Beronni M (2010) : Function-related structural plasticity of the GnRH system A role for neuronal–glial–endothelial interactions Structural plasticity in GnRH system. Frontier in Neuroendocrinology (Impact factor: 12.067) 31 (3): 241-258.

*Front cover of the journal Frontier of Neuroendocrinology: Schematic representation of endothelial–glial interactions involved in the control of GnRH neurosecretion in the median eminence. Volume 31, 2010.

    Book Published:

1. Jyoti Parkash 2016: Neuronal- Glial Plasticity in GnRH System: Novel Role of PSA-NCAM.  Pages 244 https://www.lap-publishing.com/ LAP Lambert Academic Publishing Germany

Book Chapters:

  1. Gurcharan Kaur and Jyoti Parkash 2018 : Hormones of hypothalamus and ageing published in the book ‘Hormones in Ageing and Longevity’ Publisher (springer) pages151-166.
  2. Jyoti Parkash Arti Sharma and Ankur Jairath 2018 : Embryonic stem cell as a Cellular Model for testing the toxicity of engineered nanoparticles. Published in the book ‘Nanotoxicology’ Publisher CRC Press Taylor and Francis group. pages 613-634.

 

Research Guidance

No. of Students Guided:

  1. Ph.D.

Completed - 01

Title: Design, Synthesis and Evalution of Donepzil- Rasagiline based compounds as multipotent inhibitors for the treatment of Alzheimer’s Disease (Dr. Bhupinder Singh, Department of Pharmaceutical sciences and natural products).

Submitted - 01 (Vijay Kumar)

Title: Syntheis and Evaluation of Quinazoline derivatives as multi-potent ligands for
the treatment of Alzheimer’s Disease

Supervising - 03  

Co-supervising - 01

  1. M.Sc.  Dissertation/Project

           Completed - 26

Supervising - 05 (batch 2020-21)

Under Supervision:

  1. KNDy/nNOS neurons interplay: A new possible mechanism of GnRH secretion in the adult brain (Vikash Prashar, Department of Zoology)
  2. Syntheis and Evaluation of Quinazoline derivatives as multipotent ligands for the treatment of Alzheimer’s Disease (Vijay Kumar, Department of Pharmaceutical sciences and natural products)
  3. Evaluation of Withaferin A and Tinospora cordifolia extract individually and synergistically in neuron-glial cells intoxicated with Kainic acid (Randeep Singh, Department of Zoology)
  4. Elucidation of the neuroprotective role of Adhatoda vasica by using polarized astrocytes as a model system (Tania Arora)         

 

M. Sc. Dissertation / Project Work Supervised:

  1. Role of the hypothalamic glial cells in GnRH secretion (Prahallad Mishra, M.Sc. Zoology, 2022).
  2. Kindling model of epilepsy: Limitations and advancements (Arpita Bhoi, M.Sc. Zoology, 2022)
  3. Advancement in SNP genotyping as diagnosis for Parkinson Disease (Shivani Sharma  M.Sc. Zoology, 2022).
  4. Genetics of Polycystic Ovarian Syndrome (Ananya Banerjee,  M.Sc. Zoology, 2022)
  5. The role of ghrelin and kisspeptin in regulating the hypothalamic-pituitary-gonadal axis (Sayan Gupta Msc. Zoology 2021)
  6. Roles of MicroRNAs in the pathogenesis of the Parkinson’s Disease as Therapeutic Target (Gaurav Sharma, Msc. Zoology 2021)
  7. Role of leptin in obesity and its associated health disorders: An updated review (Gulshan Kumar, Msc. Zoology 2021)
  8. Detrimental effect of epilepsy on human health: protective role of antiepileptic drugs and natural products (Pushpum, Msc. Zoology 2021)
  9. Tinospora cordifolia: A potential neuroprotective agent against various neurodegenerative diseases (Chinmoyee Bhattacharyya, M.Sc. in Life Sciences, 2020)
  10. Anti-Cancer activity of the Withaferin A: Current research and Future prospectives (Debashsis Rout, M.Sc. in Life Sciences, 2020)
  11. Tinospora cordifolia: An age-old plant with promising anti-cancer potential (Anusha Panwar, M.Sc. in Life Sciences, 2020)
  12. A review on neuroprotective effects of Withaferin A (Dukhiram Kisku, M.Sc. in Life Sciences, 2020)
  13. Comparative genomic analysis of nNOS using different bioinformatics approaches (Nymphaea Arora, M.Sc. in Life Sciences, 2019)
  14. The Comparative genomic analysis of NOS3 using different bioinformatics approaches (Arpita Banerjee, M.Sc. in Life Sciences, 2019)
  15. Comparative genomic analysis of the NOS2 gene using various bioinformatics tools (Priya Godara, M.Sc. in Life Sciences, 2019)
  16. To test the role of Withaferin A in neuroprotection on SH-SY5Y cell line challenged by Kainic acid (Aishwarya Pruseth, M.Sc. in Life Sciences, 2018)
  17. To check the glioprotective effect of Withaferin A on C6 Glioma cell culture challenged with Kainic acid (Bindu Balaya Dash, M.Sc. in Life Sciences, 2018)
  18. Molecular mechanism of the Pirfenidone activity in human lung fibroblasts (Pooja Bhaarti, M.Sc. in Life Sciences, 2018)
  19. To study the effect of Pirfenidone on Semaphorin 7A expression in A549 Cell line (Vandana Singh, M.Sc. in Life Sciences, 2017)
  20. Project on the glioprotective effects on Withania somnifera on C6 cell line challenged by Kainic Acid (Ambika Kumari, M.Sc. in Life Sciences, 2017)
  21. Project on the neuroprotective effects of Withania somnifera on SH-SY5Y cell line challenged with Kainic acid (Anjali Kharb, M.Sc. in Life Sciences, 2017).
Conference/ Workshops/Seminars Attended

 Attended Workshops:

1. Attended and completed successfully International online Faculty Development Programme on ‘Green Perspectives in Food processing sector’ Organized by Department of Food Engineering and Department of Food Science and Technology, NIFTEM Haryana from 5th to 21st Oct. 2020.

2. Attended and completed successfully National workshop on Curriculum Design and Development Organized by CUP Bathinda sponsored by INYAS India from 21st July to 31st July 2020.

3. Participated and completed successfully INYAS-CUPB Lecture Workshop ‘tangled bank’ encompassing 15 lectures organized by CUP Bathinda from 31st May to 5th June sponsored by Science Academies’ India.

4. Attended and completed successfully Science leadership workshop organized by CUP Bathinda from June 22nd  to June 28th 2020 sponsored by Science Academies’ India.

5. Participated and completed successfully AICTE Training and Learning (ATAL) Academy online FDP on ”Molecular Manufacturing” organized by CUP Bathinda from 23rd Nov. To 27th Nov.2020 sponsored by AICTE Training and Learning (ATAL) Academy.

6. Attended online webinar on ”The people and the principles behind Nature- The What, The Why and the How”  Organized by Springer Nature Group. 

7. Attended National Workshop on the Art and Science of Scholarly Communication : Writing Better Research Papers organized by DAV University on 14th March 2015.

8. Attended IBRO-Neuroscience Training School at National University Singapore, Singapore in June 2006.

9. Attended workshop on “Tools for Bio-informatics Sub-center, Department of Biotechnology, Guru Nanak Dev University, Amritsar from 3rd - 4th March, 2005.

Poster Presentations:

  1. J. Parkash, A. Loyens, S. Gallet, E. Balland, F. Pralong, J. Pastercamp, V. Prevot, P. Giacobini 2011 Semaphorin 7A expression in tanycytes is regulated by sex-steroid hormones and controls gonadotropin-releasing hormone-1 (GnRH-1) cell plasticity. 41st Annual Meeting of Neuroscience (SFN), November 12th-16th 2011, Washington DC, USA.
  2. H. N. Kumar, J. Parkash, D Mazur, W.H Colleddge, X.D’Angleomont De Tessigny, V, Prevot 2011 Nitric oxide synthesizing neurons: important mediators of Kisspeptin- GnRH neuron interactions during the estrous cycle. 41st Annual Meeting of Neuroscience (SFN), November 12th-16th 2011, Washington DC, USA.
  3. Andrea Messina*, Langlet Fanny, Chlachaki Konstantina, Roa Juan, Gallet Sarah, Jyoti Parkash, Manuel Tena-Sempere, Paolo Giacobini and Vincent Prevot 2015: MicroRNAs flip the switch for the production of hypothalamic GnRH before puberty. 40th Colloque De la societie de neuroendocrinologie international congress from 23rd - 25th September, 2015, Lille, France.
  4. N. Bellefontaine, J. Parkash, S.G. Bouret, V. Prevot 2011 Nitric oxide neurons in the preoptic area of the hypothalamus are a direct target of Leptin: Implications for the reproductive axis. 41st Annual Meeting of Neuroscience (SFN), November 12th-16th 2011, Washington DC, USA.
  5. N. Bellefontaine, E. Caron, J. Parkash, C. Vanacker, S. G. Bouret, V. Prevot Neuronal nitric oxide synthase activity is necessary for diet-induced obesity. 43rd Annual Meeting of Neuroscience (SFN), November 9th-13th 2013, San Diego, California, USA.
  6. I. Cimino, F. Casoni, A. Messina, J. Parkash, A. Loyens, S. Jamin, N. Di Clemente, D. Dewailly, V. Prevot, P. Giacobini Extra-ovarian effects of anti-müllerian hormone on the gonadotropin-releasing hormone (gnrh) neurons. 43rd Annual Meeting of Neuroscience (SFN), November 9th-13th 2013, San Diego, California, USA.
  7. J. Parkash, A. Loyens, S. Gallet, E. Balland, F. Pralong, J. Pastercamp, V. Prevot, P. Giacobini Sema7A is a Tanycytic-Secreted Guidance Molecule and Regulates GnRH Axon Outgrowth in the Adult Brain. 14th LARC Neuroscience meeting, October 2010, Lille.
  8. P. Giacobini, J. Parkash, A. Loyens, S. Gallet, E. Balland, F. Pralong, J. Pastercamp, V. Prevot 2013: Semaphorins 7A signaling in periodical neuro-glial plasticity of the hypothalamic median eminence that underlies reproduction. 43rd Annual Meeting of Neuroscience (SFN), November 9th-13th 2013, San Diego, California, USA.
  9. J. Parkash, D'Anglemont De Tassigny X, Bellefontaine N, Campagne C, Mazure D, Buée-Scherrer V and Prévot V 2010 Phosphorylation of NMDAR associated nNOS modulates hypothalamic nitric oxide production: The role of estrogen during ovarian cycle in female rats. 7th international congress of Neuroendocrinology from 7th - 11th July, Rouen, France P2-182.
  10. J. Parkash, D'Anglemont De Tassigny X, Bellefontaine N, Campagne C, Mazure D, Buée-Scherrer V and Prévot V 2010 Phosphorylation of N-methyl-D-aspartic acid receptor-associated neuronal nitric oxide synthase modulates hypothalamic nitric oxide production: The role of estrogen during ovarian cycle in female rats; 36th Colloque De la societie de neuroendocrinologie international congress from 15th - 18th September, 2009, Nice, France.
  11. V. Briz · M. Galofré, J. Parkash, V. Prevot, C. Suñol 2010: Estradiol counteracts NMDAR internalization induced by long-term exposure to dieldrin in cortical neurons. XII International Congress of Toxicology 19th -23th July 2010, Barcelona-Spain. Toxicology Letters. Volume 196, Supplement, Pages S1-S352 (17 July 2010)
  12. J. Parkash and Kaur G Potential of PSA-NCAM to Mediate Neuronal-glial interaction in GnRH Neurosecretion: Role of GABAergic and noradrenergic neurotransmitters; 29th Annual Japan Neuroscience Society (JNS) Kyoto from 19th - 21st July (Neuroscience Research, 2006).
  13. J. Parkash and Kaur G Activity dependent neuronal-glial remodeling in the ME of adult rat hypothalamus: Role of GABAergic and noradrenergic neurotransmitters; 7th Biennial Asian Pacific Society for Neurochemistry (APSN 2006) Singapore from 2nd - 5th July (Journal of Neurochemistry 98 (1): 71, 2006).
  14. J. Parkash, A. Loyens, S. Gallet, E. Balland, F. Pralong, J. Pastercamp, V. Prevot, P. Giacobini Sema7A is a tanycytic-Secreted Guidance Cue Regulates GnRH Axon Plasticity in adult Brain. 30th Annual meeting of Indian Academy of Neurosciences. 27th-30th Oct. 2012 Amritsar India.
  15. Sushil Kumar, Jyoti Parkash, Dinesh Lakhanpal and Gurcharan Kaur: Interactive effect of excitotoxicity injury and dietary restriction on neurogenesis and neurotrophic factors in adult male rat brain; International symposium on “Molecular Aspects of Brain Aging and Neurological Disorders” at Department of Biotechnology, Guru Nanak Dev University Amritsar from 28th - 29th November, 2008.
  16. Jyoti Parkash and Gurcharan Kaur: Neuronal glial interactions are involved in the control of GnRH neurosecretion in the hypothalamus of adult cycling female rats; XXIV Annual conference of Indian Academy of Neuroscience, ITRC Lucknow from 17th - 20th December (Annals of Neuroscience; 97 (13), 2006).

 

Conference/ Workshops/Seminars Organised

Conferences Organized:

  1. Member of Organizing, Scientific and Cultural committees in National Organized conference by DAV university “Emerging Trends in Host Microbe Interactions” held on April 17th-18th, 2015.

 

Peer Recognition

2016- Till date

Editorial Board Member for International Journal of Biology, Pharmaceutical and Allied Sciences (IJBPAS)

2015- Till date

Editorial Board Member for Journal of Virology and Biotechnology

2012-2013

Member Society for Neuroscience (SFN)

2005-2006

Member for Asian Pacific Society for Neurochemistry (APSN)

2005-2006

 Member for Japan Neuroscience Society (JNS)

2017- Till date

 Life member for Indian Academy of Neuroscience
Invited Talks/ Resource Person
Oral/ Invited speaker in National and International Conferences:
1. Dr. Jyoti Parkash: Emerging roles of semaphorins in synaptic plasticity : Homeostasis and diseases. Invited lecture delivered at IBRO-APRC Associate School on Lifelong Maintenance of Brain Health: Bridging the Gaps amongst
the Young, the Old and those in Between. Universiti Teknologi MARA UiTM, Bandar Puncak Alam, Selangor Malaysia from 24th Sept. To 7th Oct 2018.
2. Dr. Jyoti Parkash: Nitric oxide mediated plasticity in the metabolic brain. Invited lecture delivered at IBRO-APRC Associate School on Lifelong Maintenance of Brain Health: Bridging the Gaps amongst the Young, the Old and those in Between. Universiti Teknologi MARA UiTM, Bandar Puncak Alam, Selangor Malaysia.
3. Dr. Jyoti Parkash: Emerging role of semaphorins in neural-glial-endothelial plasticity in the adult hypothalamic median eminence. Invited lecture delivered at Development and Plasticity of the Neuroendocrine Brain Neurobese Interantional Associated Laboratory U1172. JPARC INSERM France 8 th June 2016.

4. Dr. Jyoti Parkash: Leptin dependent neuronal NO signaling facilitates reproduction in adult hypothalamic region of the brain. Invited lecture delivered at Development and Plasticity of the Neuroendocrine Brain Neurobese Interantional Associated Laboratory U1172. JPARC INSERM France 15 th June 2016.
5. Dr. Jyoti Parkash: Invited resource person to train Bachelor, Master and Ph.D. students of Dr. Vincent Prevot lab at U1172, from 3rd June 2016 to 8th July 2016, JPARC INSERM France.
6. Oral présentation entitled ”Semaphorins regulate neuro-glia plasticity in the adult hypothlamic median eminence  conference organized by DAV university, Emerging trends of Host-Microbe interactions on 17-18th April 2015.
7. Invited Resource person in a workshop (organized by Doaba College, Jalandhar) under DBT Star College Scheme Support (Ministry of Science & Technology) entitled ‘Fundamentals of animal tissue culture and its applications’ held on 18 th March 2015.
8. Won Best Presentation Award in International symposium on “Molecular Aspects of Brain Aging and Neurological Disorders” in November 2008 held at Department of Biotechnology, Guru Nanak Dev University, Amritsar, India.
9. Invited lecture on ‘Semaphorins signalling shaping the reproductive system’ International symposium on genomic medicine personalized care for you and me organized by Doaba college Jalandhar, India, on 18th Oct. 2016.
10. Invited lecture in a workshop (organized by Kanya Maha Vidayala, Jalandhar) under DBT Star College Scheme Support (Ministry of Science & Technology) entitled ‘In the domain of animal tissue culture’ held on 29 th March 2019.
11. Invited lecture ‘Role of semaphorins in GnRh regulation’ in a webinar on “Recent Advances in Animal Sciences (Neuroscience & Nanobiotechnology)” organized by Department of Zoology, Kalahandi University Odisha, India on Dt.31-05-2021
Patent Filed/ Published
PATENT FILED
 
 
PATENT PUBLISHED
Contribution Towards Institutional Building
MOU signed between Dr. Jyoti Parkash lab and Dr. Vincent Prevot (Director) lab U1172 INSERM, International Associated Laboratory NEUROBESE lab. In this MOU exchange of faculty and students has been signed between India and France research group.
Citations

Total Citations ~ 2233   H index 21          i10 Index 26

Link: https://scholar.google.co.in/citations?user=jB2tI-MAAAAJ&hl=en

Other Significant Achievements

MOU (Memorandum of Understanding) signed between the Central University of Punjab Bathinda and University of Lille2 Health and Law. The MOU was approved by executive council of CUP Bathinda on 22nd Feb. 2018 and then duly signed by the Worthy Vice Chancellor (Prof. R.K. Kohli) of the Central University of Punjab Bathinda. In this MOU exchange of faculty and students has been signed between India and France research group. This MOU will provide us the possibility to collaborate with different research groups working in the different research prospective and also give some fluidity for the exchange of faculties and students between two universities.