Professor

Contact Info
Dr. Anil Kumar Mantha
8146585958
Lab No. 408, Laboratory of “DNA Damage - Repair and Human Health”, North block, Dept. of Zoology
Dr. Anil Kumar Mantha

Professor, Department of Zoology, School of Basic Sciences

Qualification

Degree

Institution

Year

Subject

Ph.D.

Jawaharlal Nehru University (JNU),  New Delhi, India

2001-06

Life Sciences

‘The role of neurokinin B (NKB) and amyloid beta protein fragment (25-35) on molecular and biochemical correlates in aging brain functions’

M.Phil.

National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India

1998-00

Biophysics

‘Ca2+ Induced structural and functional changes in isolated rat brain mitochondria’

M.Sc.

Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, India

1996-98

Biophysics

B.Sc.

Osmania University, Hyderabad, Andhra Pradesh, India

1993-96

Microbiology, Chemistry and Botany
Experience
Teaching Experience: 

 

Position Held

 

Place of Work

 

Start Date

 

End Date

 

Total Experience*

Professor

(Direct Recruitment)

Dept. of Zoology, School of Basic Sciences, Central University of Punjab, Bathinda (PB)

14-01-2020

Till date

 

> 4 Yr. & 1 month

Professor

(Career Advancement Scheme - CAS)

Dept. of Zoology, School of Basic and Applied Sciences, Central University of Punjab, Bathinda (PB)

28-12-2018

13-01-2020

Associate Professor

Dept. of Zoology (formerly known as Animal Sciences), School of Basic and Applied Sciences, Central University of Punjab, Bathinda (PB)

28-12-2015

27-12-2018

3 Yr.

Head of the Department (HOD)

Dept. of Zoology, School of Basic Sciences, Central University of Punjab, Bathinda (PB)

29-03-2022

Till date

 

In-charge Store and Purchase Branch (Additional Charge)

Central University of Punjab, Bathinda (PB)

10-11-2022

Till date

 

Purchase Officer (Additional Charge)

Central University of Punjab, Bathinda (PB)

25-3-2022

10-11-2022

   >7 months

Head of the Department (HOD)

Dept. of Animal Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda (PB)

04-01-2016

03-01-2019

3 Yr.

Officiating in Charge (OIC)

Centre for Animal Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda (PB)

14-7-2015

03-01-2016

< 6 months

Assistant Professor

Centre for Animal Sciences (formerly known as Biosciences), School of Basic and Applied Sciences, Central University of Punjab, Bathinda (PB)

31-5-2012

27-12-2015

3 Yr. & 7 months

Adjunct Assistant Professor

Dept. of Biochemistry and Molecular Biology, University of Texas Medical Branch (UTMB), Galveston, Texas, USA

Sep. 2012

Aug. 2016

3 Yr. & 11 months

Assistant Professor (Non-Tenure Research)

Dept. of Biochemistry and Molecular Biology, University of Texas Medical Branch (UTMB), Galveston, Texas, USA

1-03-2012

25-05-2012

< 3 months

Postdoctoral Research Associate

Dept. of Biochemistry and Molecular Biology, UTMB, Galveston, Texas, USA

29-01-2006

29-02-2012

6 Yr. & 1 months

Lecturer in Biophysics

Dept. of Physiology, S.V.S. Medical College, Mahabubnagar (Telangana)

July 2001

Aug. 2001

1 month

Lecturer in Biophysics

Dept. of Physiology, M. R. Medical College, Gulbarga (KA)

Nov. 2000

July 2001

9 months

Lecturer in Biophysics

Dept. of Physiology, Vinayaka Mission’s Medical College, Karaikal (UT)

Sep. 2000

Nov. 2000

2 months

 

*Total Experience for Counting is Presented in Bold

 

Research Area
  1. Oxidative Stress and Cancer Biology.
  2. DNA Damage-Repair [Single-Strand Base Repair via Base Excision Repair (BER)-pathway] and Human Diseases.
  3. DNA Repair and Regulatory Functions of Apurinic/Apyrimidinic Endonuclease (APE1/Ref-1).
  4. Amyloid Beta (Aβ) Neurotoxicity and Alzheimer’s disease (AD).
Research Interests

My research interest underscores examining various DNA repair and regulatory proteins to understand the molecular mechanisms and pathways through which the processes associated with onset of aging, age related, and neurodegenerative disorders in developing potential therapeutic targets. I am currently working on regulatory and repair functions of AP-endonuclease (APE1) in mammalian genomes. APE1 is the main apurinic/apyrimidinic endonuclease in eukaryotic cells playing a central role in the Base Excision Repair (BER) pathway of all DNA lesions (uracil, alkylated and oxidized and abasic sites) including single-strand breaks (SSBs) and has role in co-transcriptional activation of transcription factors (TFs) such as AP-1, NF-κB, TP53 and HIF1 α, and named redox effecter factor-1 (Ref-1). APE1/Ref-1 is a vital protein with its biological activities located in two functionally distinct domains. The N-terminus, containing the nuclear localization signal (NLS) region, is principally devoted to the redox activity and protein-protein interactions, while the C-terminus exerts the enzymatic activity on the AP sites of DNA.

My own interest lies in elucidating the neuro-protective role of APE1/Ref-1 in neurological disorderAlzheimer’s disease (AD). Due to its multi-functionalnature, it is proving to be a critical target in neuronal cancer therapy for “Glioblastoma”. APE1/Ref-1’s role as a neuro-protector is an unexplored field of neurodegenerative disorders. Furthermore, the expression of APE1/Ref-1 and its sub-cellular localization is still poorly investigated in case of AD. My research work is mainly focused to understand and elucidate the molecular mechanisms of genotoxicity associated with amyloid beta (Aβ) protein deposits in human brain tissue and role of APE1/Ref-1 as a potential candidate for therapeutic intervention in AD and glioblastomausing neuronal and glial cell lines as model systems.

Research Grants/Projects
  1. Mantha AK (PI): Evaluation of neuroprotective role of Picrorhiza kurroa (Kutki) on organophosphate pesticides (OPPs) pestered neurodegenerative responses in Alzheimer’s disease model study, from the DST-SERB, New Delhi, Govt. of India, under the scheme Core Research Grant (CRG). Rs. 53.64 Lakhs for 3 years (2022-2025).
  2. DST-FIST (Rs. 75 lakhs) – as a Co-PI…. For 5 years (2020-2025).
  3. Mantha AK (PI): Mitochondrial Oxidative DNA Damage-Repair in Alzheimer’s Disease: AP-endonuclease (APE1/Ref-1) as a Potential Therapeutic Target, from the Dept. of Science & Technology (DST), New Delhi, under the Cognitive Science Research Initiative (CSI-2012). Rs. 39.91 Lakhs for 3 years (2014-18).
  4. Mantha AK (PI): Identification of APE1-associated proteome during oxidative stress conditions in glioblastoma cell lines, from Central University of Punjab, Bathinda as Research Seed Money. Rs. 3 Lakhs for 2 years (2014-16).
  5. Mantha AK (PI): Apurinic/Apyrimidinic endonuclease (APE1) as an anti-cancer therapeutic agent for Glioblastoma therapy, from UGC, New Delhi under the BSR-start up grant scheme. Rs. 6 Lakhs for 2 years (2013-2015).
  6. Mantha AK (PI): APE1/Ref-1’s Dual Functions Countering Beta Amyloid Induced Genotoxicity, from Alzheimer’s Association, USA, US $ 99,990 for 2 years (2011-2013, extended as 2012-2015).
Professional Affiliation

1. Life member, Indian Association of Neurosciences
Professional Recognition/Awards/Scholarships
Recipient of Faculty Research Award - 2022 from CUPB (under the category cumulative Impact Factor more than 15 of research publications in the academic year 2020-21).

Recipient of Faculty Research Award - 2019 from CUPB (under the category cumulative Impact Factor more than 15 of research publications in the academic year 2017-18).

Recipient of Faculty Research Award - 2018 from CUPB (under the category cumulative Impact Factor more than 15 of research publications in the academic year 2016-17).

New Investigator Research Grant from Alzheimer’s Association, USA (2011)

Young Investigator award from the Alzheimer’s Drug Discovery Foundation
(ADDF), USA (2009)

Travel award for attending the International Brain Research Organization (IBRO) Advanced School on Neuroscience - “Receptors, Channels, Messengers” at Yalta, Ukraine, from CSIR, New Delhi, India (2004)
Research Collaboration
  1. Dept. of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy.
  2. Dept. of Clinical Neurology, Udine University Hospital, Udine, Italy.
  3. Dept. of Neurology, The University of Texas Medical Branch, Galveston, TX, USA.
  4. Department of Microbiology, Central University of Punjab, Bathinda, India.
  5. Department of Pharmaceutical Sciences & Natural Products, Central University of Punjab, Bathinda, India.
  6. Department of Botany, Central University of Punjab, Bathinda, India.
  7. Department of Pharmacology, Central University of Punjab, Bathinda, India.
  8. Department of Chemistry, Central University of Punjab, Bathinda, India.
  9. Department of Computational Sciences, Central University of Punjab, Bathinda, India.
  10. Department of Environmental Science & Technology, Central University of Punjab, Bathinda, India.
Publications

Research Papers (#Corresponding Author, *Equal Author)

List of Publications (Research papers, review articles, and book chapters:

S. No.

Authors, title, journal, volume, page numbers

(*Equal first author, #Corresponding author)

Impact

Factor

ISSN No

Research Articles
 

Gupta KB, Mantha AK# and Dhiman M. Gliadin Induced Oxidative Stress and Altered Cellular Responses in Human Intestinal Cells: An in-vitro Study to Understand the Cross-Talk between the Transcription Factor Nrf-2 and Multifunctional APE1 Enzyme. J. of Biochemical and Molecular Toxicology. 2022 May 9; e23096. doi: 10.1002/jbt.23096.

 3.642 10990461

 

Gupta KB, Mantha AK and Dhiman M. Mitigation of Gliadin Induced Inflammation and Cellular Damage by Curcumin in Human Intestinal Cell Lines. Inflammation. 2021 Jan: doi.org/10.1007/s10753-020-01383-x

4.092

03603997

 

Thakur S, Sarkar B, Dhiman M, Mantha AK. Organophosphate-pesticides induced survival mechanisms, and APE1-mediated Nrf2 regulation in non-small cell lung cancer cells. J. of Biochemical and Molecular Toxicology. 2020 Oct 20:e22640. doi: 10.1002/jbt.22640.

3.642

10990461

 

Gupta SK, Verma K, Kumar R, Sarkar B, Mantha AK, Kumar S.Priming alleviates high temperature induced oxidative DNA damage and repair using Apurinic/apyrimidinic endonuclease (Ape1L) homologue in wheat (Triticum aestivum L.). Plant Physiol Biochem. 2020 Sep 16;156:304-313. doi: 10.1016/j.plaphy.2020.08.050.

4.27

09819428

 

Upadhyay S, Mantha AK, Dhiman M. Glycyrrhiza glabra (Licorice) root extract attenuates doxorubicin-induced cardiotoxicity via alleviating oxidative stress and stabilising the cardiac health in H9c2 cardiomyocytes. J Ethnopharmacol. 2020 doi: 10.1016/j.jep.2020.112690.

4.36

03788741

 

Kaur G, Cholia RP, Joshi G, Amrutkar SM, Kalra S, Mantha AK, Banerjee UC, and Kumar R. Anticancer activity of dihydropyrazolo[1,5-c]quinazolines against rat C6 glioma cells via inhibition of topoisomerase II. Arch Pharm (Weinheim). 2018. 351(6):1800023.

3.751

05214184

 

Kumar B, Dwivedi AR, Sarkar B, Gupta SK, Krishnamurthy S, Mantha AK, Parkash J, Kumar V. 4,6-Diphenylpyrimidine Derivatives as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2018 Oct 22. doi: 10.1021/acschemneuro.8b00220.

4.418

19487193

 

Kumar B, Sheetal, Mantha AK, Kumar V.  Synthesis, Biological Evaluation and Molecular Modeling Studies of Phenyl-/Benzhydrylpiperazine Derivatives as Potential MAO Inhibitors. Bioorganic Chemistry. 2018. 77: 252-262.

5.275

 

00452068

 

Cholia RP, Dhiman M, Kumar R, Mantha AK#. Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes. Metabolic Brain Disease. 2018. pp.1-20.

3.584

08857490

 

Gupta KB, Upadhyay S, Saini RG, Mantha AK and Dhiman M. Inflammatory response of gliadin protein isolated from various wheat varieties on human intestinal cell line. J. of Cereal Science. 2018: 81(2018): 91-98.

3.616

07335210

 

Thakur S, Dhiman M, and Mantha AK#. APE1 Modulates Cellular Responses to Organophosphate Pesticides Induced Oxidative Damage in Non-small Cell Lung Carcinoma A549 cells. Molecular and Cellular Biochemistry. 2017. 441(1-2):201-16.

3.396

03008177

 

Sarkar B, Dhiman M, Mittal S, and Mantha AK#. Curcumin Revitalizes Amyloid Beta (25-35)-Induced and Organophosphate Pesticides Pestered Neurotoxicity in SH-SY5Y and IMR-32 Cells via Activation of APE1 and Nrf2. Metabolic Brain Disease. 2017. 32(6):2045-61.

3.584

08857490

 

Cholia RP, Kumari S, Kumar S, Kaur M, Kaur M, Kumar R, Dhiman M, Mantha AK#. An in vitro Study Ascertaining the Role of H2O2 and Glucose Oxidase in Modulation of Antioxidant Potential and Cancer Cell Survival Mechanisms in Human U-87 MG Cells. Metabolic Brain Disease. 2017. 32(5):1705-16.

3.584

08857490

 

Sengupta S, Mantha AK, Song H, Roychoudhury S, Nath S, Ray S, Bhakat KK. Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair. Oncotarget. 2016. 7(46):75197- 75209.

3.765

19492553

 

Roychoudhury S, Nath S, Song H, Hegde ML, Bellot LJ, Mantha AK, Sengupta S, Ray S, Natarajan A, Bhakat KK. Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity. Mol Cell Biol. 2017. 37(6):e00401-16.

3.611

02707306

 

Gill I, Kaur S, Kaur N, Dhiman M, and Mantha AK#. Phytochemical Ginkgolide B attenuates Aβ(1-42)- induced oxidative damage and altered cellular responses in human neuroblastoma SH-SY5Y cells. Journal of Alzheimer’s Disease. 2017. 60(s1):S25-S40.

4.472

13872877

 

Hegde ML, Dutta A, Yang C, Mantha AK, Hegde PM, Pandey A, Sengupta S, Yu Y, Calsou P, Chen D, Lees-Miller SP and Mitra S.  Scaffold attachment factor A (SAF-A) and ku temporally regulate repair of radiation-induced clustered genome lesions. Oncotarget. 2016. 7(34):54430- 54444.

3.611

19492553

 

Bhakat KK, Sengupta S, Adeniyi VF, Roychoudhury S, Nath S, Bellot LJ, Feng D, Mantha AK, Sinha M, Qiu S, Luxon BA. Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation. Oncotarget. 2016 7(16):22590- 22604.

3.611

19492553

 

Kaur N, Dhiman M, Perez-Polo, JR, and Mantha AK#. Ginkgolide B Revamps Neuroprotective Role of APE1 and Mitochondrial OXPHOS Against Aβ(25-35)-Induced Neurotoxicity in Human Neuroblastoma Cells. J. of Neuroscience Research. 2015. 93: 938-947.

4.164

03604012

 

Tsutakawa SE, Shin DS, Mol CD, Izumi T, Arvai AS, Mantha AK, Szczesny B, Ivanov IN, Hosfield DJ, Frankel KA, Hitomi K, Cunningham RP, Mitra S, Tainer JA. Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes. J. Biological Chemistry. 2013. 288(12):8445-55.

5.157

00219258

 

Sengupta S, Chattopadhyay R, Mantha AK, Mitra S, and Bhakat KK. Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex. J. of Hypertension. 2012. 30(5): 917-925.

4.844

02636352

 

Mantha AK#, Dhiman M, Taglialatela G, Perez-Polo JR and Mitra S. Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction. J. of Neuroscience Research. 2012. 90(6): 1230-123.

4.164

03604012

 

Sengupta S, Mantha AK, Mitra S and Bhakat KK. Human AP-endonuclease (APE1/Ref-1) and its acetylation regulate YB-1/p300 recruitment and RNA polymerase II loading in the drug induced activation of multidrug resistance gene MDR1. Oncogene. 2010: 30(4):482-93. 

7.971

09509232

 

Barnes T, Kim WC, Mantha AK, Kim SE, Izumi T, Mitra S, Lee CH. Identification of apurinic/apyrimidinic endonuclease APE1 as the endoribonuclease that cleaves c-myc mRNA. Nucleic Acids Research. 2009: 37(12):3946-58.

16.971

03051048

 

Bhakat KK, Mantha AK and Mitra S. Transcriptional Regulatory Functions of Mammalian AP-endonuclease (APE1/Ref-1), an Essential Multifunctional Protein. Antioxidant Redox Signaling. 2009; 11(3): 1-17.

8.401

15577716

 

Mantha AK, Oezguen N, Izumi T, Braun W and Mitra S. Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease1. Journal of Molecular Biology. 2008; 379(1):28-37.

5.469

00222836

 

Mantha AK, Moorthy K, Cowsik SM and Baquer NZ. Membrane associated functions of neurokinin B (NKB) on Ab (25-35) induced toxicity in aging rat brain synaptosomes. Biogerontology. 2006 b; 7 (1): 19-33.

4.277

13895729

 

Mantha AK, Moorthy K, Cowsik SM and Baquer NZ. Neuroprotective role of neurokinin B (NKB) on b - amyloid (25-35) induced toxicity in aging rat brain synaptosomes: Involvement in oxidative stress and excitotoxicity. Biogerontology. 2006 a; 7(1):1-17.

4.277

13895729

 

Moorthy K, Yadav UCS, Siddiqui MR, Mantha AK, Cowsik SM, Sharma D, Basir SF and Baquer NZ. Effect of hormone replacement therapy in normalizing age related neuronal markers in different age groups of naturally menopausal rats. Biogerontology. 2005; 6(5): 345-356.

4.277

13895729

 

Mantha AK, Chandrashekar IR, Baquer NZ and Cowsik SM. Three-dimensional structure of the mammalian tachykinin peptide neurokinin B bound to lipid micelles. Journal of Biomolecular Structure and Dynamics. 2004; 22(2): 137-148.

3.549

07391102

 

Moorthy K, Yadav UC, Mantha AK, Cowsik SM, Sharma D, Basir SF and Baquer NZ. Estradiol and Progesterone treatments change the lipid profile in naturally menopausal rats from different age groups. Biogerontology. 2004; 5 (6) 411-419.

4.277

13895729
  Khan I, Sarkar B, Joshi G, Nakhate K, Ajazuddin, Mantha AK, Raj K, Kaul A, Chaturvedi S, Mishra A, Gupta U. Biodegradable nanoparticulate co-delivery of flavonoid and doxorubicin: Mechanistic exploration and evaluation of anticancer effect in vitro and in vivo. Biomaterials and Biosystems 2021. DOI: 10.1016/j.bbiosy.2021.100022. -- 26665344

 

Khan I, Joshi G, Sarkar B, Nakhate K, Ajazuddin, Mantha AK, Raj K, Kaul A, Chaturvedi S, Mishra A, Gupta U. Doxorubicin and Crocin Co-delivery by Polymeric Nanoparticles for Enhanced Anticancer Potential In Vitro and In Vivo.  ACS Applied Bio Materials. 2020; 3 (11) 7789-7799. DOI: 10.1021/acsabm.0c00974.

--

25766422

 

Upadhayay S, Sharma N, Mantha AK, and Dhiman M. Anti-cancer Drug Doxorubicin Induced Cardiotoxixity: Understanding the Mechanisms Involved through ROS Generation Resulting in Mitochondrial Dysfunction. Rasayan J. of Chemistry. 2020: 13(2): 1042-1053.

--

09741496

 

Kaur N, Kaur S, Saini M, Dhiman M, and Mantha AK#. Phytochemical Ginkgolide B Protects Cultured Neuroblastoma SH-SY5Y Cells Against Aβ(25-35) Induced Oxidative Stress Responses by Maintaining the Mitochondrial Integrity. Rasayan J. of Chemistry. 2020: 13(1): 306-321.

--

09741496

 

Oezguen N*, Mantha AK*, Izumi T, Schein CH, Mitra S and Braun W. MD simulation and experimental evidence for Mg²+ binding at the B site in human AP endonuclease 1. Bioinformation. 2011: 7(4):184-190.

--

09732063

 

Dike A, Chandrashekaran IR, Mantha AK, Baquer NZ and Cowsik SM. Pharmacophore Pattern Identification of Tachykinin Receptor Selective Peptide Agonists: Implications in Receptor Selectivity. American Journal of Biochemistry & Biotechnology. 2007: 3(4): 180-186.    

--

15533468

Review Articles
  Kaur S, Verma H, Dhiman M, Tell G, Gigli GL, Janes F, Mantha AK. Brain Exosomes: Friend or Foe in Alzheimer’s Disease? Molecular Neurobiology. 2021 Dec. DOI: 10.1007/s12035-021-02547-y 5.590 15591182

 

Verma H, Cholia RP, Kaur S, Dhiman M, Mantha AK. A short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiforme. Metab Brain Dis. 2021 Jun;36(5):751-765. doi: 10.1007/s11011-021-00690-y. Epub 2021 Mar 2.

3.584

08857490

 

Upadhyay S, Gupta KB, Mantha AK, Dhiman M. A short review: Doxorubicin and its effect on cardiac proteins. J Cell Biochem. 2020 Sep 14. doi: 10.1002/jcb.29840.

4.429

10974644

 

Mittal S, Thakur S, Mantha AK, Kaur H. Bio-analytical applications of nicking endonucleases assisted signal-amplification strategies for detection of cancer biomarkers -DNA methyl transferase and microRNA. Biosens Bioelectron. 2019. 124:233-243

10.618

09565663

 

Sarkar B, Kulharia M, and Mantha AK#. Understanding human thiol dioxygenase enzymes: structure to function and biology to pathology. International J. of Experimental Pathology; 2017. 98(2):52-66.

1.925

09599673

 

Mittal S, Kaur H, Gautam N, Mantha AK. Biosensors for breast cancer diagnosis: A review of bioreceptors, biotransducers and signal amplification strategies. Biosens Bioelectron. 2017. 88:217-231.

10.618

09565663

 

Kumar B, Sheetal, Mantha AK, and Kumar V. Recent Developments on the Structure-Activity Relationship Studies of MAO Inhibitors and Their Role in Different Neurological Disorders. RSC Adv. 2016. 6(48):42660-83.

3.361

20462069

 

Cholia RP, Kumar R, and Mantha AK#. Understanding the Multifaceted Role of Ectonucleotide Pyrophosphatase/ Phosphodiesterase 2 (ENPP2) and its Altered Behavior in Human Diseases. Current Molecular Medicine. 2015. 15(10):932-943. 

1.600

15665240

 

Thakur S, Dhiman, M, Tell G, and Mantha AK#. A Review on Protein-Protein Interaction Network of APE1/Ref-1 and its Associated Biological Functions. Cell Biochemistry & Function. 2015. 33(3): 101-112. 

3.685

02636484

 

Kaur G, Cholia RP, Mantha AK#, Kumar R. DNA repair and redox activities and inhibitors of APE1/Ref-1: A comparative analysis and their scope and limitations toward anticancer drug development. J. of Medicinal Chemistry. 2014. 57(24):10241-10256.

7.446

0222623

 

Gautam N, Mantha AK#, Mittal S. Essential Oils and their Constituents as Anti-cancer Agents: A Mechanistic View. BioMed Research International. 2014. DOI: 10.1155/2014/154106.

3.411

23146133

 

Thakur S, Sarkar B, Cholia RP, Gautam N, Dhiman M, Mantha AK#. APE1/Ref-1 as an Emerging Therapeutic Target for Various Human Diseases: Phytochemical Modulation of its Functions. Experimental and Molecular Medicine. 2014. 46(7):e106.

5.418

12263613

 

Mantha AK#, Sarkar B, Tell G. A short review on the implications of base excision repair pathway for neurons: Relevance to neurodegenerative diseases. Mitochondrion. 2013. 16: 38-49.

4.16

15677249

 

Mantha AK#. APE1: A Molecule of Focus with Neuroprotective and Anti-Cancer Properties. J. of Biotechnology & Biomaterials. 2013: 3(3).

--

2155952X

 

Hegde ML, Mantha AK, Hazra TK, Bhakat KK, Mitra S, and Szczesny B. Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases. Mechanism of Aging and Development. 2012. 133(4): 157-168.

5.432

00476374

Book Chapters

ISBN
  Kaur S, Midha T, Verma H, Muduli R.R., Dutta O, Saini O, Prakash R, Sharma S, Mantha A.K., and Dhiman M. Bioremediation: A favorable perspective to eliminate heavy metals from polluted soil. Metagenomics to Bioremediation. 2022; Academic Press. pp-209-230 Ed. by Vineet Kumar -- 978-0-323-96113-4
  Kaur S., Verma H., Kaur S., Singh S., Mantha A.K., Dhiman M. Herbal Remedies for Improving Cancer Treatment Through Modulation of Redox Balance. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. 2022. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_270-1. -- 978-981-16-1247-3

 

Gupta KB, Kaur S, Dhiman M, and Mantha AK#.. Methods to assess oxidative DNA base damage repair of apurinic/apyrimidinic (AP) sites using radioactive and non-radioactive oligonucleotides based assays. Cancer Biomarkers: Methods and Protocols. . 2022; 2413: 155-163. doi: 10.1007/978-1-0716-1896-7_16.  Springer publisher.

 

--

978-1-0716-1895-0

 

Kaur S, Gupta KB, Kumar S, Upadhyay S, Mantha AK, and Dhiman M. Methods to Detect Nitric Oxide and Reactive Nitrogen Species in Biological Sample. Cancer Biomarkers: Methods and Protocols. 2022; 2413: 69-76. doi: 10.1007/978-1-0716-1896-7_9. Springer publisher.

 

--

978-1-0716-1895-0

 

Kaur S, Dhiman M, and Mantha AK#. Ferulic Acid: A Natural Antioxidant with Applications toward Neuroprotection against Alzheimer’s disease. Functional foods and Human Health. 2018. Springer Publishers. pp-575-586

 

--

 

978-981-13-1122-2

 

Upadhyay S, Gupta KB, Kaur S, Rubal, Kumar S, Mantha AK and Dhiman M. Resveratrol: A Miracle Drug for Vascular Pathologies. Functional foods and Human Health. 2018. Springer Publishers. pp-119-142

 

--

 

978-981-13-1122-2

 

Kaur N, Sarkar B, Gill I, Kaur S, Mittal S, Dhiman M, Padala PR, Perez-Polo JR, and Mantha AK#. Indian herbs and their therapeutic potential against Alzheimer’s disease and other neurological disorders. Neuroprotective Effects of Phytochemicals in Neurological Disorders. 2016. Wiley Publishers. pp-79-112

 

--

 

978-1-119-15514-0

 

Kaur N, Sarkar B, Mittal S, Dhiman M, Taglialatela G, Perez-Polo RJ, Mantha AK#. Oxidative Stress Events and Neuronal Dysfunction in Alzheimer’s Disease: Focus on APE1/Ref-1 Mediated Survival Strategies. Free Radicals in Human Health and Disease, Oxidative Stress and Human Health. 2014. Springer publishers. pp-175-208

 

--

 

978-81-322-2034-3

 

Dhiman M, Thakur S, Upadhyay S, Kaur A, Mantha AK. Oxidative Stress and Inflammation in Cardiovascular Diseases: Two Sides of the Same Coin. Free Radicals in Human Health and Disease, Oxidative Stress and Human Health. 2014. Springer publishers. pp-259-278

 

--

 

978-81-322-2034-3

 

 

 

Research Guidance
  1. Research Associate – 01

 

  1. Ph.D.  [Completed – 06]
  1. Influence of Wheat Protein Gliadin on Oxidative Stress, Inflammation and Associated Signaling Pathways in Human Intestinal Cells (Dr. Kunj Bihari Gupta, Biochemistry and Microbial Sciences, May 2021).
  2. An In Vitro Study to Evaluate the Effect of Viola pilosa and Glycerrhiza glabra Extracts on Doxorubicin Induced Cardiotoxicity in H9c2 Cardiomyocytes. (Dr. Shishir Upadhyay, Biosciences, November 2020).
  3. Evaluation of Amyloid Beta (Aβ)-Induced Mitochondrial Dysfunction: Neuroprotective Role of Apurinic/Apyrimidinic Endonuclease 1 (APE1) Via its Interaction with Cysteamine Dioxygenase (ADO). (Dr. Navrattan Kaur, Biosciences, June 2020).
  4. Organophosphate Pesticides Pester Aβ-Induced Genotoxic Responses In Cultured Neuronal Cells: APE1/Ref-1 Mediated Intervention. (Dr. Bibekananda Sarkar, 2018).
  5. A Biochemical Study to Evaluate the Role of Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Lung Cancer Progression. (Dr. Shweta Thakur, 2018)
  6. Oxidative Stress Induced Cell Proliferation and DNA Repair Mechanisms in Glioblastoma Cells: Role of ENPP2 and APE1. (Dr. Ravi P. Cholia, 2017).

Supervising- 04 & Co-supervising - 01

  1. In Vitro Study on Aβ Induced Innate Immune Responses and Neuroprotection by Ferulic Acid (Sharanjot Kaur, Biochemistry and Microbial Sciences).
  2. Harkomal Verma, Zoology
  3. Prabhakar Gangawar, Zoology
  4. Anuradha, Zoology
  5. Rashmi, Zoology
  1. M.Phil. [Completed- 07] & M.Pharma. [Completed- 03 as co-supervisor]
  1. Effect of Amyloid Beta (25-35) Peptide on Mitochondrial Respiratory Function in Neuronal Cells Over-Expressing APE1. (Navrattan Kaur, Biosciences, 2014)
  2. Understanding the Oxidative Stress Responses and Antioxidants State in Differentiated Neurons. (Sukhchain Kaur, Biosciences, 2016).
  3. In vitro Study of Oxidative Stress Induced DNA-damage Responses in Differentiated Neurons. (Iqbal Gill, Biosciences, 2016).
  4. Doxorubicin Induced Cardiotoxicity through Mitochondrial Dysfunction. (Nidhi Sharma, Biosciences, 2016)
  5. Evaluation of Antioxidant Potential of Ferulic acid Against Aβ(25-35) Induced Oxidative Stress Response in Human Neuroblastoma (SH-SY5Y) Cells (Sharanjot Kaur, Biosciences, 2016).
  6. To Study the Expression Pattern of Key Neuronal Proteins Modulated by Ferulic Acid Against Aβ(25-35) Induced Oxidative Stress in SH-SY5Y Cells (Aditi Dhawan, Biosciences, 2016).
  7. Identification of Oxidative Stress Induced Neoantigen in Human Lung Cancer A549 Cell Line. (Saurabh Vaish, Biosciences, 2017)
  1. Design and synthesis of APE1 inhibitors as putative anticancer agents (Gagandeep Kaur, 2014, M.Pharma).
  2. Synthesis of Some Piperazine Containing Scaffolds as Potential MAO Inhibitors (Sheetal Menia, 2014, M.Pharma).
  3. Design, Synthesis and Screening of Phenylpiperazine Derivatives as Putative MAO Inhibitors (Bhupinder Kumar, 2015, M.Pharma).
  1. M.Sc.   [Completed – 28]
  1. An In vitro Study on Oxidative Stress Induced Superoxide Dismutase (SOD) Activity in Human Glioblastoma (U-87 MG) Cells. (Manbir Kaur, M.Sc. Biosciences, 2014).
  2. Assessment of Antioxidant Potential of Phytochemicals in Human Glioblastoma (U-87 MG) Cells. (Manpreet Kaur, M.Sc. Biosciences, 2014).
  3. Pollen Induced Stress in Human Lung Carcinoma A549 Cells. (Rekha Atri, M.Sc. Biosciences, 2014).
  4. To Understand the Role of Cellular Antioxidant Enzymes in Oxidative Stress Environment in Human Glioblastoma (U-87 MG) cells (Sanju Kumari, M.Sc. Biosciences, 2016).
  5. Implications of Signalling Pathways in Pollen Induced Inflammation in A549 Lung Carcinoma Cell line. (Amrit Pal Kaur, M.Sc. Biosciences, 2016).
  6. Synthesis and Characterization of Cationic Polymeric Nanoparticles and Evaluation of their Bioactivities. (Heerak Chugh, M.Sc. Biosciences, 2016).
  7. To Evaluate the Antioxidant Properties of Ethnobotanical Plants of Himachal Pradesh. (Manisha Rani, M.Sc. Biosciences, 2016).
  8. Understanding the Role of Oxidative Stress and Mitochondrial Functioning in Human Glioblastoma U-87 MG cells. (Saurabh Kumar, M.Sc. Biosciences, 2016).
  9.  Evaluation of Role of Curcumin in Modulation of APE1’s Expression in Human Neuroblastoma SH-SY5Y Cells. (Daljeet Kaur, M.Sc. Biosciences, 2016).
  10. Effect of Ferulic Acid on the Expression Levels of DNA Repair Enzymes Against Aβ(25-35) Induced Oxidative Stress in Human Neuroblastoma (SH-SY5Y) cells. (Tania Devi, M.Sc. Life Sciences sp. Animal Sciences, 2017)
  11. Effect of Curcumin on the Expression levels of Different Enzymes Against Oxidative Stress Induced by Chlorpyrifos in Human Neuroblastoma (SH-SY5Y) cells. (Varinder Singh, M.Sc. Life Sciences sp. Animal Sciences, 2017).
  12. Ginkgolide B Modulates BER Pathway Enzymes in the Presence of Amyloid β(25-35)- induced Oxidative Stress. (Meenu Saini, M.Sc. Life Sciences sp. Animal Sciences, 2017).
  13. Neuro-protective role of Ginkgolide B in Aβ-induced Neurodegeneration and AChE enzyme Activity in Human Neuroblastoma SH-SY5Y cells. (Ankita Mukherjee, M.Sc. Life Sciences sp. Animal Sciences, 2018).
  14. Role of Curcumin on Monoamine Oxidase (MAO) Enzyme Expression and Activity Against Amyloid Beta (Aβ)-Induced Oxidative Stress in Human Neuroblastoma U-87 MG cells. (Nishibala N Behera, M.Sc. Life Sciences sp. Animal Sciences, 2018).
  15. Neuroprotective Role of Alpha-Tocopherol Against Aβ(25-35) Induced Oxidative Stress Responses in Cultured Neuroblastoma SH-SY5Y Cells. (Akash, M.Sc. Life Sciences sp. Animal Sciences, 2019).
  16. To evaluate the neuroprotective role of α-Tocopherol via the modulation of antioxidant enzymes in Aβ(25-35) induced oxidative stress responses in SH-SY5Y cells. (Neha Tiwari, M.Sc. Life Sciences sp. Animal Sciences, 2019).
  17.  To Study The Neuroprotective Potential of α-Tocopherol In SH-SY5Y Cells by Modulating DNA Damage and Repair Enzyme APE1. (Golden Kumar, M.Sc. Life Sciences sp. Animal Sciences, 2019).
  18. Evaluation of LPS-induced Oxidative Stress Responses in Human Neuroblastoma SH-SY5Y Cells. (Paris Thakiyal, M.Sc. Life Sciences sp. Animal Sciences, 2020).
  19. Neuroinflammation: A Key Player in Alzheimer’s Disease Pathology. (Narinder Kumar, M.Sc. Life Sciences sp. Animal Sciences, 2020).
  20. Inflammation in Alzheimer’s Disease: Role of TREM2 Receptor. (Jayashree Niharika, M.Sc. Life Sciences sp. Animal Sciences, 2020).
  21. Effect of organophosphate pesticides on microglia leading to Alzheimer’s disease. (Binit Kumar Sahu, M.Sc. Life Sciences sp. Animal Sciences, 2021).
  22. Crosstalk Influence of Astrocytes in Synaptic Transmission. (Mahesh Kumar, M.Sc. Life Sciences sp. Animal Sciences, 2021).
  23. Effects of Organophosphate Pesticides on Astroglial cells Leading to Alzheimer’s Disease. (Kumari Riya Pati, M.Sc. Life Sciences sp. Animal Sciences, 2021).
  24. Effects of Organophosphate compounds on neuronal cells leading to Alzheimer’s Disease. (Swastitapa Kar, M.Sc. Life Sciences sp. Animal Sciences, 2021).
  25. Influence of multifunctional enzyme APE1/Ref-1 in glioblastoma pathophysiology (Ashutosh, M.Sc. Zoology, 2022).
  26. Understanding the path towards drug targeting of multifunctional enzyme APE1’s activators and inhibitors in human cancers. (Madhurima Mukherjee, M.Sc. Zoology, 2022).
  27. Neuroinflammation: role of astrocytes and microglial activation in Alzheimer’s disease. (Megha Singh, M.Sc. Zoology, 2022).
  28. Understanding the neuroinflammation and synaptic functionality: role of APE1 and Alzheimer’s disease. (Divya, Rohilla, M.Sc. Zoology, 2022).
Conference/ Workshops/Seminars Attended
  1. Kaur M, Kaur M, Dhiman M, Mantha AK. Assessment of Antioxidant Potential of Phytochemicals in Human Glioblastoma (U-87 MG) Cells. Bhubaneswar, Dec. 18-21, 2014.
  2. Kaur N, Dhiman M, Perez-Polo JR, and Mantha AK. Phytochemical modulation of APE1-mediated neuronal survival along with mitochondrial OXPHOS against Aβ-induced neurotoxicity: A synergistic mechanism of neuroprotection. Bengaluru, Nov. 1-3, 2014.
  3. Mantha AK, Dhiman M, Taglialatela G. Amyloid beta induced gentotoxicity: what protects neurons? Cuttak, Nov. 9-11, 2013.
  4. Oxidative Stress Induced Modulation of SOD and APE1: Key Towards Survival of Glioblastoma Cells. Allahabad, October, 24-27, 2013.
  5. Mantha AK, Dineley KT, Perez-Polo JR and Mitra S. Neuroprotective Role of APE1/Ref-1 in Amyloid Beta Mediated Genotoxicity in Neuronal Precursor PC12 Cells. November 12, 2009 at UTMB, Galveston, TX, USA.
  6. Mantha AK, Oezguen N, Izumi T, Bhakat KK, Mitra S and Braun W. Does the APE1 Double Mutant E96Q, D210N Bind Mg2+ in the Active Site? February 19 to 24, 2009 at Galveston, TX, USA.
  7. Mantha AK, Chandrashekar IR, Dike A, Moorthy K, Baquer NZ and Cowsik SM. Role of Neurokinin B and Ab-protein fragment 25-35 on aging rat brain synaptosomes. The XXIst International Conference on Magnetic Resonance in Biological Systems, January 16 to 21, 2005 at Hyderabad, India.
  8. Mantha AK, Chandrashekar IR, Moorthy K, Baquer NZ and Cowsik SM. Tachykinin NK-3 Receptor and its Agonist Neurokinin B (NKB) Interactions: Shedding Light on Aging Brain Functions. IBRO Advanced School on Neuroscience “Receptors, Channels, Messengers”, September 16 to 28, 2004 at Yalta, Ukraine.
  9. Mantha AK, Chandrashekar IR, Dike A, Baquer NZ and Cowsik SM. Three-dimensional structure of the mammalian tachykinin peptide neurokinin B bound to lipid micelles: A NK3 receptor agonist of mammalian origin involved in neuroprotection and Aging. NMRS 2004 [National Magnetic Resonance Society] Symposium on NMR Drug Design & Bioinformatics, February 17 to 20, 2004 at Kolkata, India.
  10. Vidyasagar S, Mantha AK and Kulkarni SG. Evaluation of radiation exposure doses from television. National Symposium on Radiation and Molecular Biophysics, Bhabha Atomic Research Centre (BARC), January 21 to 24, 1998 at Mumbai, India.
Conference/ Workshops/Seminars Organised
  1. Two-day work shop on “Functional Proteomics” organized in collaboration with the Dept. of Biochemistry and Microbial Sciences; and Dept. of Chemical Sciences, 8th – 9th Oct. 2018, Central University of Punjab, Bathinda.
  1. Socio-Legal & Other Challenges for the Prevention of Drug Abuse in India: Existing Approaches & Agenda of Reform, October 2017, Central University of Punjab, Bathinda.
  1. One-day national symposium on “Recent Trends in Biological Sciences” on 29th March 2016, Bathinda.
  1. Earth day celebration in collaboration with Punjab Pollution Control Board, May 2016.
  1. One day national Workshop on "Training the Teachers - Water Quality and Health" on Feb.11, 2015, Bathinda

 

Peer Recognition

2010 - Till date

Reviewed manuscripts for highly reputed International Journals

2016 – 2017

Editorial board member, Journal of Alzheimer’s Disease, USA

2012 – 2014

Editorial board member, Journal of Biotechnology and Biomaterials

2011 - 2015

Alzheimer’s Association, USA

2003 - 2004

Indian Biophysical Society
Invited Talks/ Resource Person
1. Apurinic/Apyrimidinic Endonuclease 1 (APE1) Acts as a Critical Node for the Survival against Organophosphate-pesticides (OPPs) Induced Oxidative Stress in Non-small Cell Lung Cancer Cells, at the 13th International Symposium on Cancer Prevention & Treatment, February 20-21, 2020, JNU, New Delhi, India.

2. Organophosphate pesticides induce survival mechanisms and modulates APE1 cellular functions in non-small cell lung cancer cells, at the “International Symposium “on Tumor Microenvironment and Cancer Prevention & Therapeutics, February 8 - 9, 2019, JNU, New Delhi, India.

3. Oxidative Stress Stimulates Metastatic Potential via Activation and Cross-talk between the Enzymes APE1, PKM2, and ENPP2 in Rat C6 and Human U-87 MG Glioblastoma Cells, at the “International Symposium on Cancer Prevention and Treatment”, February 9 - 10, 2018, JNU, New Delhi, India.

4. Neuroprotective role of Curcumin against Amyloid Beta (25-35)-Induced and Organophosphate Pesticides Pestered Neurotoxicity in SH-SY5Y and IMR-32 Cells via Activation of APE1 and Nrf2-mediated Pathways, October 29 – November 3, 2017, Ravenshaw University, Cuttack, India.

5. Biology of Amyloid Beta-induced Oxidative Stress in Alzheimer’s Disease: An association of Mammalian Thiol Dioxygenase, ADO with the Human AP-Endonuclease 1 (APE1) Towards Neuroprotection, February, 10-11, 2017, JNU, New Delhi, India.

6. Understanding the role of oxidative stress in GBM progression and development of phytochemical based therapeutic interventions. CRCA-International Symposium on Role of Herbals in Cancer Prevention and Treatment, February 9-10, 2016, JNU, New Delhi, India.

7. Accentuating the role of multifunctional enzyme APE1/Ref-1 in renovation of mitochondrial functioning by Ginkgolide B against Amyloid β-mediated mitochondrial dysfunction in Alzheimer’s disease. IBRO School on Mitochondria and Neurodegeneration, October 26th -30th, 2015, Chandigarh, India.

8. Understanding the neuroprotective role of APE1/Ref-1 and it’s interaction with ADO against Amyloid β-mediated mitochondrial dysfunction in Alzheimer’s disease. XXXIII - IAN conference at Punjab University, October 31st – November 2nd, 2015, Chandigarh, India.
Citations

google scholar

  All
Citations (2008 onwards) 2606  
h-index 28  
i10-index 41