School of Basic and Applied Science

Department of Biochemistry


The Department of Biochemistry within the School of Basic and Applied Sciences started as an independent department in 2015 with an aim to train the students in the fields of biochemistry and microbiology and to encourage interdisciplinary activities among the faculty. The Department has internationally trained faculty with wide research and teaching experience. The Department is currently engaged in active research and with several research projects funded by various funding agencies such as DST and DBT. The department strives to synergize the study of biochemistry and microbiology with health disparities research through innovation and collaboration and to provide the highest quality of translational biomedical research, education, and service. The internationally trained faculty of the centre is committed to provide outstanding teaching in the biochemical and microbial sciences and to conduct quality research of international repute and promote R&D activities in the emerging areas of biochemistry and microbiology. The department is involved in the community service and awareness programs related to medical biochemistry and microbiology. The focus of the department is to:
  • Provide state of the art educational and research training for students.
  • Provide students excellent opportunities to explore the dynamic fields of biomedical including clinical biochemistry, immune-pharmacology, immunology, and drug research.
Research Thrust Areas
  1. Cancer Biology
  2. Plant Natural Products
  3. Immunology of Clinically Relevant Diseases
  4. Systems Biology
  5. Host Microbe Interactions

Faculty

  1. Dr. Ramakrishna Wusirika, Professor, Professor
  2. Dr. Malkhey Verma, Associate Professor, HOD
  3. Dr. Shashank Kumar, Assistant Professor
  4. Dr. Manju Jain,Assistant Professor
  5. Dr. Rajan Vyas, Ramalingaswami Re-entry Fellow

Academic Programmes Offered

  1. Ph.D. Biochemistry
  2. Ph.D. Microbial Sciences
  3. M. Sc. Life Sciences with specialization in Biochemistry
  4. M. Sc. Life Sciences with specialization in Microbial Sciences

Syllabi

2018-20

2017-19

2016-17

2015-16

Research Highlights/ Areas

  • Molecular and Cellular Biology of Gastro-intestinal Cancer
  • Development of novel plant natural products as anti-cancer drugs
  • Synthetic System Biology and Bioprocess Engineering
  • Role of metal resistant bacteria and mycorrhiza in enhancing plant growth and metal uptake by modulating metabolic pathways
  • Chemotherapy induced toxicity
  • Signaling pathways during Inflammation and oxidative stress in various human diseases
  • Drug and Vaccine development to Visceral leishmaniasis (Kalazar)
  • Understanding immuno-biology of clinically relevant diseases associated with an abnormal T cell effector immune response

Laboratory Facilities

The department has the following equipment:
  • Centrifuge
  • Microscopes
  • Water Bath
  • Refrigerators
  • Laminar air flow cabinet
  • PCR machine
  • Mini sub cell GT – horizontal gel electrophoresis unit
  • Rotamantle
  • BOD incubator
  • Incubator shaker
  • Autoclaves
  • Spectrophotometer
  • Digital analytical balance

The department has access to well-equipped teaching and research laboratories with the following equipment:

  • Ultra-low temperature freezers
  • Cell culture facility
  • CO2 incubators
  • Laminar air flow cabinets
  • Real-time PCR
  • DNA sequencer
  • Gel documentation system

The department also has access to the following equipment in the Central Instrumentation Laboratory (CIL):

  • Confocal Microscope
  • Scanning Electron Microscope
  • GC-MS
  • UHPLC
  • Flow Cytometer
  • Atomic Absorption Spectrometer
  • Fourier Transform Infrared Spectrometer
  • ICP-MS

Publication

Dr. Ramakrishna Wusirika, Professor, Centre Coordinator
Peer-reviewed Research Publications

  • Dhawi F, Datta R, Ramakrishna W (2017) Proteomics provides insights into biological pathways altered by plant growth promoting bacteria and arbuscular mycorrhiza in sorghum grown in marginal soil. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1865 (2): 243-251. Impact Factor 2.9
  • Rahman N, Dhadi SR, Deshpande A, Ramakrishna W (2016) Rice callus suspension culture inhibits growth of cell lines of multiple cancer types and induces apoptosis in lung cancer cell line. BMC Complementary and Alternative Medicine 16 (1), 427. Impact Factor 2.3
  • Dhawi F, Datta R, Ramakrishna W (2016) Mycorrhiza and heavy metal resistant bacteria enhance growth, nutrient uptake and alter metabolic profile of sorghum grown in marginal soil. Chemosphere 157, 33-41. Impact Factor 4.5
  • Pidatala VR, Li K, Sarkar D, Ramakrishna W, Datta R. (2016) Identification of biochemical pathways associated with lead tolerance and detoxification in Chrysopogon zizanioides L. Nash (Vetiver) by metabolic profiling. Environmental Science and Technology 50:2530-2537. Impact Factor 6.2
  • Dhawi F, Datta R, Ramakrishna W. (2015) Mycorrhiza and PGPB modulate maize biomass, nutrient uptake and metabolic pathways in maize grown in mining-impacted soil. Plant Physiology and Biochemistry 97:390-399. Impact Factor 3.3
  • Dhadi SR, Xu Z, Shaik R,  Driscoll K, Ramakrishna W. (2015)  Differential regulation of genes by retrotransposons in rice promoters. Plant Molecular Biology 87:603-613. Impact Factor 4.3
  • Li K, Pidatala VR, Shaik R, Datta R, Ramakrishna W. (2014) Integrated metabolomic and proteomic approaches dissect the effect of metal resistant bacteria on maize biomass and copper uptake.  Environmental Science and Technology 48:1184–1193. Impact Factor 5.3
  • Shaik R, Ramakrishna W.  (2014) Machine learning approaches distinguish multiple stress conditions using stress-responsive genes and identify candidate genes for broad resistance in rice. Plant Physiology 164:481-495. Impact Factor 8
  • Shaik R, Ramakrishna W. (2013) Genes and coexpression modules common to drought and bacterial stress responses in Arabidopsis and rice.  PloS One 8:e77261. Impact Factor 3.2
  • Dhadi SR, Deshpande A, Driscoll K, Ramakrishna W. (2013) Major cis-regulatory elements for rice bidirectional promoter activity reside in the 5’-untranslated regions. Gene 526:400–410. Impact Factor 2.1
  • Rafi S, Ramakrishna W.  (2012) Bioinformatic analysis of epigenetic and microRNA mediated regulation of drought responsive genes in rice. PloS One 7:e49331. Impact Factor 3.2
  • Li K, Pidatala RR, Ramakrishna W.  (2012) Mutational, proteomic and metabolomic analysis of a plant growth promoting copper-resistant Pseudomonas spp. FEMS Microbiology Letters 335:140–148. Impact Factor 2.1
  • Deshpande AD, Dhadi SR, Hager E, Ramakrishna W.  (2012) Rice callus suspension cultures inhibit growth of two cancer cell lines. Phytotherapy Research 26:1075–1081. Impact Factor 2.7
  • Krom N, Ramakrishna, W. (2012) Retrotransposon insertions in rice gene pairs associated with reduced conservation of gene pairs in grass genomes. Genomics 99:308-14. Impact Factor 3.3
  • Dhadi SR, Deshpande A, Ramakrishna W. (2012) A novel nonwounding transient expression assay for cereals mediated by Agrobacterium tumefaciens.  Plant Molecular Biology Reporter 30:36-45. Impact Factor 1.7
  • Li K, Ramakrishna W. (2011) Effect of multiple metal resistant bacteria from contaminated lake sediments on metal accumulation and plant growth. Journal of Hazardous Materials 189:531-539. Impact Factor 4.5
  • Xu Z, Rafi S, Ramakrishna W. (2011) Polymorphisms and evolutionary history of retrotransposon insertions in rice promoters.  Genome 54:629-638. Impact Factor 1.7
  • Krom N, Ramakrishna W. (2011) Conservation, rearrangement, and deletion of gene pairs during the evolution of four grass genomes.  DNA Research 17:343-352. Impact Factor 5.5
  • Dhadi SR, Krom N, Ramakrishna W. (2009) Genome-wide comparative analysis of putative bidirectional promoters from rice, Arabidopsis, and Populus.  Gene 429:65-73.  Impact Factor 2.1
  • Krom, N, Ramakrishna W. (2008) Comparative analysis of divergent and convergent gene pairs and their expression patterns in rice, Arabidopsis, and PopulusPlant Physiology  147:1763-1773. Impact Factor 8
  • Krom, N, Recla J, Ramakrishna W. (2008) Analysis of genes associated with retrotransposons in the rice genome.  Genetica 134:297-310. Impact Factor 2.2
  • Xu Z, Ramakrishna W.  (2008)Retrotransposon insertion polymorphisms in six rice genes and their evolutionary history.  Gene 412:50-58.  Impact Factor 2.1
  • Oakley RV, Wang Y-S, Ramakrishna W, Harding SA, Tsai CJ. (2007) Differential expansion and expression of α- and β-tubulin gene families in Populus.  Plant Physiology 145:961-973. Impact Factor 8
  • Nagy E, Lee T-C, Ramakrishna W, Xu Z, Klein P, SanMiguel P, Cheng C-P, Li J, Devos K, Schertz K, Dunkle L, Bennetzen J.  (2007) Fine mapping of the Pc locus of Sorghum bicolor, a gene controlling the reaction to a fungal pathogen and its host-selective toxin. Theoretical Applied Genetics 114:961-970. Impact Factor 3.8
  • Gorantla M, Babu P, Reddy Lachagari V, Reddy A, Wusirika R, Bennetzen JL, Reddy AR.  (2007) Identification of stress-responsive genes in an indica rice (Oryza sativa L.) using ESTs generated from drought-stressed seedlings. Journal of Experimental Botany 58:253-265. Impact Factor 5.5
  • Lai J, Ma J, Swigonova Z, Ramakrishna W, Linton E, Llaca V, Tanyolac B, Park YJ, Jeong OY, Bennetzen JL, Messing J (2004) Gene loss and movement in the maize genome.  Genome Research 14:1924-1931.  Impact Factor 13.9
  • Swigonova Z, Lai J, Ma J, Ramakrishna W, Llaca V, Bennetzen JL, Messing J. (2004) Close split of sorghum and maize genome progenitors.  Genome Research 14:1916-1923. Impact Factor 13.9
  • Yan L, Loukoianov A, Blechl A, Tranquilli G, Ramakrishna W, SanMiguel P, Bennetzen JL, Echenique V, Dubcovsky J.  (2004) The wheat VRN2 gene is a flowering repressor down-regulated by vernalization. Science 303:1640-1644. Impact Factor 33.6
  • Bennetzen JL, Coleman C, Liu R, Ma J, Ramakrishna W (2004) Consistent over-estimation of gene number in complex plant genomes.  Current Opinion in Plant Biology 7:732-736. Impact Factor 7.9
  • Swigonova Z, Lai JS, Ma JX, Ramakrishna W, Llaca M, Bennetzen JL, Messing J. (2004) On the tetraploid origin of the maize genome. Comparative Functional Genomics 5:281-284. Impact Factor 2
  • Ramakrishna W, Deng Z, Ding CK, Handa AK, Ozminkowski RH Jr. (2003) A novel small heat shock protein gene, vis1, contributes to pectin depolymerization and juice viscosity in tomato fruit. Plant Physiology, 131:725-735. Impact Factor 8
  • Ramakrishna W, Dubcovsky J, Park Y-J, Busso C, Emberton J, SanMiguel P, Bennetzen JL.              (2002) Different types and rates of genome evolution detected by comparative sequence analysis of orthologous segments from four cereal genomes.  Genetics 162:1389-1400. Impact Factor 6
  • Ramakrishna W, Emberton J, Ogden M, SanMiguel P, Bennetzen JL. (2002). Structural analysis of the maize Rp1 complex uncovers numerous sites and unexpected mechanisms of local rearrangement.  Plant Cell 4:3213-3223. Impact Factor 10.5
  • Ramakrishna W, Emberton J, SanMiguel P, Ogden M, Llaca V, Messing J, Bennetzen JL. (2002) Comparative sequence analysis of the sorghum Rph region and the maize Rp1 resistance gene complex. Plant Physiology 130:1728-1738. Impact Factor 8
  • Bennetzen JL, Ramakrishna W. (2002) Numerous small rearrangements of gene content, order and orientation differentiate grass genomes.  Plant Mol Biol 48:821-827. Impact Factor 4.3
  • Yan L, Echenique V, Busso C, SanMiguel P, Ramakrishna W, Bennetzen JL, Harrington S, Dubcovsky J.  (2002) Cereal genes similar to Snf2 define a new subfamily that includes human and mouse genes. Molecular Genetics Genomics 268:488-499. Impact Factor 2.7
  • Stam M, Belele C, Ramakrishna W, Dorweiler JE, Bennetzen JL, Chandler VL. (2002) The regulatory regions required for B' paramutation and expression are located far upstream of the maize b1 transcribed sequences. Genetics 162:917-930. Impact Factor 6
  • Bennetzen JL, Ramakrishna W.  (2002)Exceptional haplotype variation in maize. Proceedings of the National Academy of Sciences USA 99:9093-9095. Impact Factor 9.7

Dr. Dr. Malkhey Verma, Associate Professor
Peer-reviewed research publications

  • Sawaya MR, Verma M, Balendiran V, Rath NP, Cascio D, Balendiran GK (2016). Characterization of WY 14,643 and its Complex with Aldose Reductase. Scientific Reports 6:34394.
  • Mondeel TDGA, Rehman S, Zhang Y, Verma M, Dürre P, Barberis M, Westerhoff HV (2016). Maps for when the living gets tough: Maneuvering through a hostile energy landscape. IFAC-PapersOnLine 49-26: 364–370.
  • Bragg S, Verma M, Moser RJ and Balendiran GK (2015). Kinetics of the Solid State Pyrolysis of Gellan Gum and Paper Pulp. Journal of Biobased Materials and Bioenergy Vol. 9, 1-8.
  • Balendiran K, Ganesaratnam, Rajendran Pandian, J., Drake, Evin, Vinayak Anubhav, Verma M, Cascio Duilio (2014). B-factor Analysis and Conformational Rearrangement of Aldose Reductase. Current Proteomics 11(3): 151-160.
  • Ettore Murabito, Malkhey Verma, Martijn Bekker, Domenico Bellomo, Hans V. Westerhoff, Bas Teusink, Ralf Steuer (2014). Monte-Carlo Modeling of the Central Carbon Metabolism of Lactococcus lactis: Insights into Metabolic Regulation. PLoS ONE 9(9): e106453
  • M Verma, EG Karimiani, RJ Byers, S Rehman, HV Westerhoff, PJR Day (2013). Mathematical modelling of miRNA mediated BCR-ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies. Integrative Biology 5(3): 543-54.
  • M Verma, M Zakhartsev, M Reuss, HV Westerhoff (2012). ‘Domino’ systems biology and the ‘A’of ATP. Biochimica et Biophysica Acta (BBA)-Bioenergetics 1827(1): 19-29.
  • GK Balendiran, MR Sawaya, FP Schwarz, G Ponniah, R Cuckovich, M Verma, D Cascio (2011). The role of Cys-298 in aldose reductase function. Journal of Biological Chemistry 286 (8): 6336-6344
  • HV Westerhoff, M Verma, M Nardelli, M Adamczyk, K van Eunen, E Simeonidis (2010). Systems Analysis of Metabolism. Biochemical Society transactions 38 (part 5): 1189-1196.
  • HV Westerhoff, C Winder, H Messiha, E Simeonidis, M Adamczyk, M Verma, FJ (2009). Systems biology: the elements and principles of life. FEBS letters 583 (24): 3882-3890.
  • M Verma, HJ Martin, W Haq, TR O'Connor, E Maser, GK Balendiran (2008). Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers. European journal of pharmacology 584(2): 213-221.
  • GK Balendiran, M Verma, E Perry (2007). Chemistory of fibrates. Current Chemical Biology 1(3): 311-316
  • M Verma, S Rawool, PJ Bhat, KV Venkatesh (2006). Biological significance of autoregulation through steady state analysis of genetic networks. Biosystems 84(1): 39-48
  • M Verma, PJ Bhat, KV Venkatesh (2005). Steady-state analysis of glucose repression reveals hierarchical expression of proteins under Mig1p control in Saccharomyces cerevisiae. Biochemical Journal 388 (Pt 3): 843-849.
  • A Ruhela, M Verma, JS Edwards, PJ Bhat, S Bhartiya, KV Venkatesh (2004). Autoregulation of regulatory proteins is key for dynamic operation of GAL switch in Saccharomyces cerevisiae. FEBS Letter 576(1-2): 119-126.
  • M Verma, PJ Bhat, KV Venkatesh (2004). Expression of GAL genes in a mutant strain of Saccharomyces cerevisiae lacking GAL80: quantitative model and experimental verification. Biotechnology and Applied Biochemistry 39(1): 89-97.
  • M Verma, PJ Bhat, S Bhartiya, KV Venkatesh (2004). Steady state modeling approach to validate an in vivo mechanism of the GAL regulatory network in Saccharomyces cerevisiae. European Journal of Biochemistry 271 (20): 4064-4074.
  • M Verma, PJ Bhat, KV Venkatesh (2003). Quantitative analysis of GAL genetic switch of Saccharomyces cerevisiae reveals that nucleocytoplasmic shuttling of Gal80p results in a highly sensitive response to galactose. Journal of Biological Chemistry 278 (49): 48764-48769.
  • E Murabito, R Colombo, Cn Wu, M Verma, S Rehman, J Snoep, S-L Peng, N Guan, HV Westerhoff (2015). SupraBiology 2014: Promoting UK-China collaboration on Systems Biology and High Performance Computing. Quantitative Biology: 2015: eScholarID: 259998. DOI:10.1007/s4048401500399

Dr. Shashank Kumar, Assistant Professor
Peer-reviewed research publications

  • Bais S S, Lawrence K, Kumar S, Lawrence R (2015). Eichhornia crassipes (Mart.) Solm: A biotic resource for waste water treatment. World J Pharmaceut Sci. 3:1
  • Sanjay S S, Pandey A C, Kumar  S, Pandey A K. (2014).Membrane protective efficacy of ZnO nanoparticles,” OP Transactions on Nano-technology. 1:1, 21-29
  • Kumar S and Pandey AK. (2014). Medicinal attributes of S. xanthocarpum fruit consumed by several tribal communities as food: An antioxidant, anticancer and anti HIV perspective,” BMC Comp Alt Med, 14:112
  • Kumar S, Pandey S, Pandey A. K. (2014). In vitro antibacterial, antioxidant, cytotoxic activities of Parthenium hysterophorus and characterization of extracts by LC MS analysis. BioMed Research International (Formerly titled Journal of Biomedicine and Biotechnology). Article ID 495154
  • Kumar S, and Pandey A. K. (2014). Preliminary evaluation of biological activities and phytochemical analysis of Syngonium podophyllum leaf. National Academy Science Letters, 38:2, 143-146
  • Kumar S, Kumar R, Diwedi A, and Pandey A. K. (2014). In vitro antioxidant, antibacterial, cytotoxic activity and in vivo efficacy of Syngonium podophyllum and Eichhornia crassipes leaf extracts on isoniazid induced oxidative stress and hepatic markers. BioMed Res Int. 2014: Article ID 459452
  • Sharma A K, Kumar S and Pandey A K. (2014). Cell cycle inhibitory activity of Piper longum against A549 cell line and its protective effect against metal-induced toxicity in rats. Ind J Biochem Biophys. 2014, 51, October
  • Sharma A K, Kumar S and Pandey A K. (2014). Ferric reducing, antiradical and cytotoxic activites of Tinospora cordifolia stem extract. Biochem Anal Biochem. 3:2
  • Mishra A, Kumar S and Pandey AK. (2013). Scientific validation of the medicinal efficacy of Tinospora cordifolia,” Scientific World J, 2013, Article ID 292934.
  • Kumar S, Chashoo G, Saxena AK and Pandey AK, (2013). Parthenium hysterophorus: a probable source of anticancer, antioxidant and anti-HIV agent. BioMed Res Int., 2013: Article ID 810734
  • Mishra A, Sharma AK, Kumar S, Saxena AK and Pandey AK. (2013). Bauhinia variegata leaf extracts exhibit considerable antibacterial, antioxidant and anticancer activities. BioMed Res Int, 2013: Article ID 915436, 10 pages.
  • Kumar S, Gupta AK and Pandey AK. (2013) Calotropis procera root extract has capability to combat free radical mediated damage. ISRN Pharmacol, 2013: Article ID 691372
  • Kumar S, Mishra A, and Pandey AK. (2013) Antioxidant mediated protective effect of Parthenium hysterophorus against oxidative damage using in vitro models. BMC Comp Alt Med, 13:120
  • Kumar S, and Pandey AK.. (2013). Phenolic content, reducing power and membrane protective activities of Solanum xanthocarpum root extracts. Vegetos- An Int J Plant Res, 26, 301-307
  • Kumar S, Sharma UK, Sharma AK and Pandey AK. (2012). Protective efficacy of Solanum xanthocarpum root extracts against free radical damage: phytochemical analysis and antioxidant effect.  Cell Mol Biol, 58, 171-178.
  • Kumar S, and Pandey AK. (2012.) Antioxidant, lipo-protective and antibacterial activities of phytoconstituents present in Solanum xanthocarpum root. Int Rev Biophysical Chem, 3, 42-47
  • Mishra A, Kumar S, Bhargava, A, Sharma, B, and Pandey, A.K. (2011). Studies on in vitro antioxidant and anti staphylococcal activities of some important medicinal plants, Cell Mol Biol, 57, 16-25
  • Pandey A K, Mishra A, Kumar S, and Chandra, A. (2010). Therapeutic Potential of C. zeylanicum extracts: An antifungal and antioxidant perspective, Int J Biol Med Res. 1(4): 228-233
  • Kumar S and Pandey AK. (2015). Free radicals, from oxidative stress to disease and their mitigation by herbals, British J Med Med Res. 7 (6), 438-457
  • Kumar S and Pandey AK. (2014). Pharmacological activities of some common Indian weeds: A review, Mintage J Pharmaceut Med Sci, 3, 12-17
  • Kumar S, Gupta R, Kaleem AM, Pandey AK. (2014). Mitigation of pain and anesthetic drugs, OA Anaesthetics, 2 (1): 2
  • Pandey A K, and Kumar S. (2014) Perspective on plant products as antimicrobials agents: A review, Pharmacologia4: 469-480
  • Kumar S (2015). MicroRNAs an evolving prognostic, diagnostic and therapeutic target in prostate cancer. World J Pharmaceut Sci. 3:3, 387-389
  • Kumar R, Diwedi A, Kumar S and Pandey A. K. (2014) Effect of Eichhornia crassipes leaf aqueous extract on isoniazid induced oxidative stress and hepatic markers in albino wistar rats. In: Proceedings of All India Seminar on Recent Advances in Biotechnology and Human Health Care (March 2014). Editors R. Shrivastava, and B. Modhera, 1-7
  • Kumar S, and Pandey, AK, (2013) Phytochemicals analysis, cytotoxic and radical scavenging activities of Parthenium hysterophorus. In: Proceedings of Intl Conf on health, environment and industrial biotechnology (ICHEIB BioSangam 2013). Editor S. Sharma, McGraw Hill Education (India) Pvt Ltd., New Delhi. pp 271-274. ISBN (13): 978-9-33-290137-7

 Review Articles Published

  • Kumar S, Ahamad MK, Waseem M, Pandey AK (2015). Drug targets for cancer treatment: An overview, Med Chem. 5:3, 115-123
  • Kumar S and Pandey AK. (2013). Chemistry and Biological Activities of Flavonoids: An Overview. Scientific World J, 2013,Article ID162750.
  • Kumar S (2014). Emerging trends in pharmaceutical sciences: An introduction. World J Pharmaceut Sci. 2:12, 1592-1593
Dr. Manju Jain, Assistant Professor
Peer-reviewed research publications
  • Khandelwal A, Malhotra A, Jain M, Vasquez KM, Jain A. (2017). The emerging role of long non-coding RNA in gallbladder cancer pathogenesis. Biochimie 132:152-160
  • D Lomada, M Jain*, M Reddy, R Kang, J DiGiovanni, E Richie, (2016). Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells” mTEC development , Plos Genetics. * Equal first co-author, Impact Factor 7.53
  • M Jain and R Madhubala, (2008). Characterization and localization of ORFF gene from the LD1 locus of Leishmania donovani. Gene, Jun 15; 416 (1-2): 1-10, Impact Factor 2.18
  • B Sukumaran, M Jain, PJ Myler, KD Stuart and R Madhubala, (2007). Creation of Tetracycline Regulatable Knockouts of ORFF Gene from the LD1 Locus of Leishmania donovani. American Journal of Biochemistry and Biotechnology 3(4): 207-215
  • M Jain, VS Dole, PJ Myler, KD Stuart and Ra Madhubala, (2007). Role of Biopterin Transporter (BT1) Gene on Growth and Infectivity of Leishmania. American Journal of Biochemistry and Biotechnology 3(4): 199-206
  • P Tewary, M Jain, MH Sahani, S Saxena and R Madhubala, (2005). A heterologous prime boost vaccination regime using ORFF DNA and recombinant ORFF protein confers protective immunity against experimental visceral leishmaniasis. J. Infec. Diseases 191: 2130-2137, Impact Factor 6.2

List of the Research Projects Operational in the Department

  1. Dhiman, M. Chemotherapeutic Drug Induced Cardiomyocyte Toxicity: Evaluation of Ethno-Botanical Plants to Minimize the Cardiac Damage. Funded by Dept. of Science and Technology (DST), New Delhi. PI (22 Lakhs) (2013-17)
  2. Dhiman, M. Mitochondrial Oxidative DNA Damage-Repair in Alzheimer’s disease: AP-endonuclease (APE1/Ref-1) as a Potential Therapeutic Target. Funded by DST, New Delhi. Co-investigator (46 Lakhs) (2014-17).
  3. Somesh, B. Role of Integrin binding protein, kindlin in colon cancer progression. Funded by Dept. of Biotechnology (DBT). PI (88 Lakhs) (2015-2020)
  4. Pramod, K. Functional characterization of the guanylate binding proteins- interferon- γ- inducible 65- KD GTPases in host immune response to Leishmania pathogenesis. Funded by DST, New Delhi. PI (35 Lakhs) (2014-2019)
  5. Somesh B. Role of Nischarin in regulation of intestinal apical epithelial junction. Funded by DST. PI (50 Lakhs) (2017-2020)
  6. Somesh B. Identification and characterization of functional significance of gastric cancer stem cells. Funded by UGC-FRP Scheme. PI (10 Lakhs) (2017-2019)
  7. Shashank K. Effect of Withania somnifera phytoconstituents on miRNA expression profile in breast cells: Therapeutic and Cytoprotective role.  Funded by DST, New Delhi. PI             (50 Lakhs) (2017-2021)
  8. Shashank K. Identification and validation of novel notch signaling pathway inhibitors as potential anticancer agents of natural origin. Funded by UGC. PI (10 Lakhs) (2017-2019)
  9. Manju J.  Investigating the role of thymus in mediating host immune- modulation in Visceral Leishmaniasis. Funded by DST-SERB Fast Track. PI (30.3 Lakhs) (2014-2018)
  10. Ramakrishna W.  Identification of best combination of plant growth promoting bacteria and arbuscular mycorrhizae for enhancing yield and nutrient content of wheat and dissecting associated biological pathways using proteomics and metabolomics. Funded by DST-SERB. PI (38.2 Lakhs) (2017-2020)

Schedule for the PhD student presentations in current semester